| Drug General Information |
| Drug ID |
D01SWO
|
| Former ID |
DNC003576
|
| Drug Name |
2-(3-hydroxyphenyl)-1,2'-spirobi[1H-indene]-5-ol
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C23H18O2
|
| Canonical SMILES |
C1C2=CC=CC=C2CC13C4=C(C=C(C=C4)O)C=C3C5=CC(=CC=C5)O
|
| InChI |
1S/C23H18O2/c24-19-7-3-6-15(10-19)22-12-18-11-20(25)8-9-21(18)23(22)13-16-4-1-2-5-17(16)14-23/h1-12,24-25H,13-14H2
|
| InChIKey |
NBNSBPOETAKHET-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Estrogen receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Estrogen receptor beta |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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Estrogen signaling pathway
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Prolactin signaling pathway
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Thyroid hormone signaling pathway
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Endocrine and other factor-regulated calcium reabsorption
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Proteoglycans in cancerhsa04915:Estrogen signaling pathway
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NetPath Pathway
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FSH Signaling Pathway
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EGFR1 Signaling Pathway
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RANKL Signaling Pathway
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Pathway Interaction Database
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Regulation of nuclear SMAD2/3 signaling
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Signaling events mediated by HDAC Class II
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Plasma membrane estrogen receptor signaling
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LKB1 signaling events
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Regulation of Telomerase
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ATF-2 transcription factor network
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AP-1 transcription factor network
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FOXM1 transcription factor network
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Validated nuclear estrogen receptor alpha network
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Signaling mediated by p38-alpha and p38-beta
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FOXA1 transcription factor networker_nongenomic_pathway:Plasma membrane estrogen receptor signaling
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Validated nuclear estrogen receptor beta network
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Reactome
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Nuclear signaling by ERBB4
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Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathway
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WikiPathways
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Estrogen signaling pathway
|
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Nuclear Receptors Meta-Pathway
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Estrogen Receptor Pathway
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Signaling by ERBB4
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JAK/STAT
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Integrated Pancreatic Cancer Pathway
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Leptin signaling pathway
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miR-targeted genes in muscle cell - TarBase
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Integrated Breast Cancer Pathway
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Nuclear ReceptorsWP706:SIDS Susceptibility Pathways
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Ovarian Infertility Genes
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Nuclear Receptors
|
| References |
| REF 1 | Bioorg Med Chem Lett. 2003 Feb 10;13(3):479-83.2-Phenylspiroindenes: a novel class of selective estrogen receptor modulators (SERMs). |
|---|
