| Drug General Information |
| Drug ID |
D03HTT
|
| Former ID |
DNC006338
|
| Drug Name |
4-(isoquinolin-5-yl)-N-o-tolylphthalazin-1-amine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C24H18N4
|
| Canonical SMILES |
CC1=CC=CC=C1NC2=NN=C(C3=CC=CC=C32)C4=CC=CC5=C4C=CN=C5
|
| InChI |
1S/C24H18N4/c1-16-7-2-5-12-22(16)26-24-21-10-4-3-9-20(21)23(27-28-24)19-11-6-8-17-15-25-14-13-18(17)19/h2-15H,1H3,(H,26,28)
|
| InChIKey |
AQWOEJFWZLDYCH-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Vascular endothelial growth factor receptor 2 |
Target Info |
Inhibitor |
[1]
|
|---|
| mRNA of VEGFR1 |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Ras signaling pathway
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|
Rap1 signaling pathway
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Cytokine-cytokine receptor interaction
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Endocytosis
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PI3K-Akt signaling pathway
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VEGF signaling pathway
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Focal adhesion
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Proteoglycans in cancerhsa04014:Ras signaling pathway
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HIF-1 signaling pathway
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Transcriptional misregulation in cancer
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Rheumatoid arthritis
|
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NetPath Pathway
|
IL2 Signaling Pathway
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PANTHER Pathway
|
Angiogenesis
|
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VEGF signaling pathway
|
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Pathway Interaction Database
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HIF-2-alpha transcription factor network
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Beta3 integrin cell surface interactions
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Signaling events mediated by TCPTP
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SHP2 signaling
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S1P1 pathway
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VEGF and VEGFR signaling network
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Integrins in angiogenesis
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Signaling events mediated by VEGFR1 and VEGFR2
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Notch-mediated HES/HEY networkglypican_1pathway:Glypican 1 network
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S1P3 pathway
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VEGFR1 specific signals
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Reactome
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Neurophilin interactions with VEGF and VEGFR
|
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VEGF binds to VEGFR leading to receptor dimerization
|
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Integrin cell surface interactions
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EPHA-mediated growth cone collapse
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VEGFA-VEGFR2 Pathway
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VEGFR2 mediated cell proliferationR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
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WikiPathways
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Focal Adhesion
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Nifedipine Activity
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Cardiac Progenitor Differentiation
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Signaling by VEGF
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AngiogenesisWP306:Focal Adhesion
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|
Angiogenesis
|
| References |
| REF 1 | Bioorg Med Chem Lett. 2006 Mar 15;16(6):1579-81. Epub 2005 Dec 28.Arylphthalazines. Part 2: 1-(Isoquinolin-5-yl)-4-arylamino phthalazines as potent inhibitors of VEGF receptors I and II. |
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