Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D03VMX
|
||||
| Former ID |
DIB019978
|
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| Drug Name |
GW1100
|
||||
| Synonyms |
GW1100; GW 1100; GW-1100
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C27H25FN4O4S
|
||||
| InChI |
InChI=1S/C27H25FN4O4S/c1-3-35-25(34)20-7-11-23(12-8-20)32-16-21(13-19-14-29-26(30-15-19)36-4-2)24(33)31-27(32)37-17-18-5-9-22(28)10-6-18/h5-12,14-16H,3-4,13,17H2,1-2H3
|
||||
| InChIKey |
PTPNCCWOTBBVJR-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | GPR40 | Target Info | Antagonist | [2] | |
| KEGG Pathway | Insulin secretion | ||||
| Reactome | G alpha (q) signalling events | ||||
| Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Incretin Synthesis, Secretion, and Inactivation | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Integration of energy metabolism | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1057). | ||||
| REF 2 | Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules. Br J Pharmacol. 2006 Jul;148(5):619-28. Epub 2006 May 15. | ||||
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