| Drug General Information |
| Drug ID |
D04QCF
|
| Former ID |
DNC008391
|
| Drug Name |
AS-601245
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C20H16N6S
|
| InChI |
InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,25H,7,10H2,(H,23,24,26)/b19-15+
|
| InChIKey |
AVLYNJZZQYEFEA-XDJHFCHBSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
26758996, 42501134, 46535496, 53790218, 57376623, 77934538, 99302750, 103459815, 134345596, 135351279, 139264934, 141074720, 163687852, 175607490, 178102619, 180372398, 204370501, 237337770
|
| Target and Pathway |
| Target(s) |
Mitogen-activated protein kinase 10 |
Target Info |
Inhibitor |
[2]
|
|---|
| mRNA of human Jun-N-terminal kinase-2 (JNK2) |
Target Info |
Inhibitor |
[3]
|
| Mitogen-activated protein kinase 8 |
Target Info |
Inhibitor |
[3]
|
| Glycogen synthase kinase-3 beta |
Target Info |
Inhibitor |
[3]
|
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KEGG Pathway
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MAPK signaling pathway
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ErbB signaling pathway
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Ras signaling pathway
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cAMP signaling pathway
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FoxO signaling pathway
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Sphingolipid signaling pathway
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Protein processing in endoplasmic reticulum
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Wnt signaling pathway
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Osteoclast differentiation
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Focal adhesion
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Toll-like receptor signaling pathway
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NOD-like receptor signaling pathway
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RIG-I-like receptor signaling pathway
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Fc epsilon RI signaling pathway
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TNF signaling pathway
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Neurotrophin signaling pathway
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Retrograde endocannabinoid signaling
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Dopaminergic synapse
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Inflammatory mediator regulation of TRP channels
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Insulin signaling pathway
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GnRH signaling pathway
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Progesterone-mediated oocyte maturation
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Prolactin signaling pathway
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Adipocytokine signaling pathway
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Type II diabetes mellitus
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Non-alcoholic fatty liver disease (NAFLD)
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Epithelial cell signaling in Helicobacter pylori infection
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Shigellosis
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Salmonella infection
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Pertussis
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Chagas disease (American trypanosomiasis)
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Toxoplasmosis
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Tuberculosis
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Hepatitis C
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Hepatitis B
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Influenza A
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Herpes simplex infection
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Epstein-Barr virus infection
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Pathways in cancer
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Colorectal cancer
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Pancreatic cancer
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Choline metabolism in cancerhsa04010:MAPK signaling pathway
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T cell receptor signaling pathway
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HTLV-I infection
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Choline metabolism in cancerhsa04012:ErbB signaling pathway
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Chemokine signaling pathway
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Cell cycle
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PI3K-Akt signaling pathway
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Hedgehog signaling pathway
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Axon guidance
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Hippo signaling pathway
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Signaling pathways regulating pluripotency of stem cells
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B cell receptor signaling pathway
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Melanogenesis
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Thyroid hormone signaling pathway
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Alzheimer's disease
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Measles
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Endometrial cancer
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Prostate cancer
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Basal cell carcinoma
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NetPath Pathway
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IL5 Signaling Pathway
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TNFalpha Signaling Pathway
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PANTHER Pathway
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Alzheimer disease-amyloid secretase pathway
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Apoptosis signaling pathway
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B cell activation
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EGF receptor signaling pathway
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FAS signaling pathway
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FGF signaling pathway
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Integrin signalling pathway
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Interferon-gamma signaling pathway
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Parkinson disease
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TGF-beta signaling pathway
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Ras Pathway
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CCKR signaling map STP00003:Alzheimer disease-amyloid secretase pathway
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Huntington disease
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Oxidative stress response
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T cell activation
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Toll receptor signaling pathway
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Angiogenesis
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PDGF signaling pathway
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CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
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Cadherin signaling pathway
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Hedgehog signaling pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Insulin/IGF pathway-protein kinase B signaling cascade
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Interleukin signaling pathway
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PI3 kinase pathway
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Wnt signaling pathway
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CCKR signaling map ST
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Pathway Interaction Database
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Noncanonical Wnt signaling pathway
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CD40/CD40L signaling
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FAS (CD95) signaling pathway
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Glucocorticoid receptor regulatory network
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FoxO family signaling
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p75(NTR)-mediated signaling
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ErbB2/ErbB3 signaling events
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PDGFR-beta signaling pathway
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Nephrin/Neph1 signaling in the kidney podocytewnt_noncanonical_pathway:Noncanonical Wnt signaling pathway
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CDC42 signaling events
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Role of Calcineurin-dependent NFAT signaling in lymphocytes
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IL2-mediated signaling events
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Rapid glucocorticoid signaling
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ErbB1 downstream signaling
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ATF-2 transcription factor network
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Nephrin/Neph1 signaling in the kidney podocyte
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p53 pathway
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Downstream signaling in naï
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RAC1 signaling pathway
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Regulation of retinoblastoma protein
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Signaling events mediated by focal adhesion kinase
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Glypican 3 network
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IL12 signaling mediated by STAT4fcer1pathway:Fc-epsilon receptor I signaling in mast cells
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Endothelins
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BCR signaling pathway
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RhoA signaling pathway
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Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
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Osteopontin-mediated events
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Reelin signaling pathway
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TRAIL signaling pathway
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Signaling events regulated by Ret tyrosine kinase
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Angiopoietin receptor Tie2-mediated signaling
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IL1-mediated signaling events
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Ceramide signaling pathway
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Regulation of Androgen receptor activity
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JNK signaling in the CD4+ TCR pathway
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HIV-1 Nef: Negative effector of Fas and TNF-alpha
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Retinoic acid receptors-mediated signaling
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Signaling events mediated by Stem cell factor receptor (c-Kit)
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EPO signaling pathway
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Syndecan-2-mediated signaling events
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Ephrin B reverse signaling
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N-cadherin signaling events
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S1P2 pathway
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IL12 signaling mediated by STAT4lysophospholipid_pathway:LPA receptor mediated events
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Degradation of beta catenin
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Presenilin action in Notch and Wnt signaling
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Integrin-linked kinase signaling
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LKB1 signaling events
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Canonical Wnt signaling pathway
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C-MYC pathway
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BMP receptor signaling
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Hedgehog signaling events mediated by Gli proteins
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Validated transcriptional targets of deltaNp63 isoforms
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Aurora A signaling
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Insulin-mediated glucose transport
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Class I PI3K signaling events mediated by Akt
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Trk receptor signaling mediated by PI3K and PLC-gamma
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PathWhiz Pathway
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Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
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Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
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Fc Epsilon Receptor I Signaling in Mast Cells
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Reactome
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Oxidative Stress Induced Senescence
|
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FCERI mediated MAPK activation
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JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
|
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Activation of the AP-1 family of transcription factorsR-HSA-2559580:Oxidative Stress Induced Senescence
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Activation of the AP-1 family of transcription factorsR-HSA-193648:NRAGE signals death through JNK
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NRIF signals cell death from the nucleus
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DSCAM interactions
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Activation of the AP-1 family of transcription factors
|
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Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksR-HSA-195253:Degradation of beta-catenin by the destruction complex
|
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AKT phosphorylates targets in the cytosol
|
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Regulation of HSF1-mediated heat shock response
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CRMPs in Sema3A signaling
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Disassembly of the destruction complex and recruitment of AXIN to the membrane
|
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S33 mutants of beta-catenin aren't phosphorylated
|
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S37 mutants of beta-catenin aren't phosphorylated
|
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S45 mutants of beta-catenin aren't phosphorylated
|
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T41 mutants of beta-catenin aren't phosphorylated
|
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Degradation of GLI2 by the proteasome
|
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Constitutive Signaling by AKT1 E17K in Cancer
|
|
WikiPathways
|
Toll-like receptor signaling pathway
|
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DNA Damage Response (only ATM dependent)
|
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G13 Signaling Pathway
|
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Insulin Signaling
|
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Wnt Signaling Pathway
|
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MAPK Cascade
|
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Oxidative Stress
|
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Wnt Signaling Pathway and Pluripotency
|
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Apoptosis Modulation by HSP70
|
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MAPK Signaling Pathway
|
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Nanoparticle-mediated activation of receptor signaling
|
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Structural Pathway of Interleukin 1 (IL-1)
|
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Apoptosis
|
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BDNF signaling pathway
|
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Integrin-mediated Cell Adhesion
|
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Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway
|
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TCR Signaling Pathway
|
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TGF Beta Signaling Pathway
|
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EGF/EGFR Signaling Pathway
|
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TGF beta Signaling Pathway
|
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Wnt Signaling Pathway Netpath
|
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JAK/STAT
|
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ATM Signaling Pathway
|
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Integrated Pancreatic Cancer Pathway
|
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Oncostatin M Signaling Pathway
|
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Corticotropin-releasing hormone
|
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AGE/RAGE pathway
|
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TNF alpha Signaling Pathway
|
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B Cell Receptor Signaling Pathway
|
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TSLP Signaling Pathway
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TWEAK Signaling Pathway
|
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RANKL/RANK Signaling Pathway
|
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IL-1 signaling pathway
|
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ErbB Signaling Pathway
|
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FAS pathway and Stress induction of HSP regulation
|
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Signaling of Hepatocyte Growth Factor Receptor
|
|
Kit receptor signaling pathway
|
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Transcriptional activation by NRF2
|
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NLR Proteins
|
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IL-3 Signaling Pathway
|
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Cardiac Hypertrophic Response
|
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EBV LMP1 signaling
|
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PDGF Pathway
|
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Nanoparticle triggered regulated necrosis
|
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Prostate Cancer
|
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Leptin signaling pathway
|
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Signalling by NGF
|
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Intrinsic Pathway for Apoptosis
|
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DSCAM interactions
|
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Apoptosis Modulation and Signaling
|
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Type II diabetes mellitus
|
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MicroRNAs in cardiomyocyte hypertrophy
|
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Physiological and Pathological Hypertrophy of the Heart
|
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Regulation of toll-like receptor signaling pathway
|
|
Osteoclast SignalingWP710:DNA Damage Response (only ATM dependent)
|
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Senescence and Autophagy in Cancer
|
|
Notch Signaling Pathway
|
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Glycogen Metabolism
|
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IL-6 signaling pathway
|
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Copper homeostasis
|
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Focal Adhesion
|
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Hair Follicle Development: Induction (Part 1 of 3)
|
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Degradation of beta-catenin by the destruction complex
|
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T-Cell Receptor and Co-stimulatory Signaling
|
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Cardiac Progenitor Differentiation
|
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IL17 signaling pathway
|
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Neural Crest Differentiation
|
|
Alzheimers Disease
|
|
IL-7 Signaling Pathway
|
|
Regulation of Microtubule Cytoskeleton
|
|
Semaphorin interactions
|
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Cell Cycle
|
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Androgen receptor signaling pathway
|
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IL-5 Signaling Pathway
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5997). |
|---|
| REF 2 | Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. Epub 2007 Dec 11.A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
|---|
| REF 3 | Biochem J. 2007 Dec 15;408(3):297-315.The selectivity of protein kinase inhibitors: a further update. |
|---|
