Drug Information
Drug General Information | |||||
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Drug ID |
D04SMQ
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Former ID |
DNC004363
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Drug Name |
(S)-WILLARDIINE
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [1] | ||
Structure |
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Download2D MOL |
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Formula |
C7H9N3O4
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Canonical SMILES |
C1=CN(C(=O)NC1=O)CC(C(=O)O)N
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InChI |
1S/C7H9N3O4/c8-4(6(12)13)3-10-2-1-5(11)9-7(10)14/h1-2,4H,3,8H2,(H,12,13)(H,9,11,14)/t4-/m0/s1
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InChIKey |
FACUYWPMDKTVFU-BYPYZUCNSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Glutamate receptor 1 | Target Info | Inhibitor | [1] | |
Glutamate receptor AMPA subtype | Target Info | Inhibitor | [1] | ||
KEGG Pathway | cAMP signaling pathway | ||||
Neuroactive ligand-receptor interaction | |||||
Circadian entrainment | |||||
Long-term potentiation | |||||
Retrograde endocannabinoid signaling | |||||
Glutamatergic synapse | |||||
Dopaminergic synapse | |||||
Long-term depression | |||||
Amyotrophic lateral sclerosis (ALS) | |||||
Amphetamine addiction | |||||
Nicotine addiction | |||||
PANTHER Pathway | Ionotropic glutamate receptor pathway | ||||
Metabotropic glutamate receptor group III pathway | |||||
Pathway Interaction Database | EPHB forward signaling | ||||
Reactome | COPII (Coat Protein 2) Mediated Vesicle Transport | ||||
Trafficking of AMPA receptors | |||||
Trafficking of GluR2-containing AMPA receptors | |||||
Unblocking of NMDA receptor, glutamate binding and activation | |||||
Cargo concentration in the ER | |||||
WikiPathways | Hypothetical Network for Drug Addiction | ||||
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
Amyotrophic lateral sclerosis (ALS) | |||||
BDNF signaling pathway | |||||
References | |||||
REF 1 | J Med Chem. 1997 Oct 24;40(22):3645-50.Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes. | ||||
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