Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D05QTX
|
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| Former ID |
DIB020626
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| Drug Name |
Org27569
|
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| Synonyms |
Org 27569
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C24H28ClN3O
|
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| InChI |
InChI=1S/C24H28ClN3O/c1-2-20-21-16-18(25)8-11-22(21)27-23(20)24(29)26-13-12-17-6-9-19(10-7-17)28-14-4-3-5-15-28/h6-11,16,27H,2-5,12-15H2,1H3,(H,26,29)
|
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| InChIKey |
AHFZDNYNXFMRFQ-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
90341443, 104253193, 120140535, 124757323, 125164127, 135698815, 136348244, 136367539, 152258523, 160647358, 160698730, 160869022, 162011818, 162038062, 162205096, 163122471, 163564970, 174531084, 176238999, 178233167, 185972545, 188919889, 204362481, 215783629, 223366181, 223601165, 242059896, 246776465, 249797656, 252079880, 252156902, 252215959
|
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| Target and Pathway | |||||
| Target(s) | Cannabinoid receptor 1 | Target Info | Modulator (allosteric modulator) | [2] | |
| KEGG Pathway | Rap1 signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Retrograde endocannabinoid signaling | |||||
| PANTHER Pathway | Endogenous cannabinoid signaling | ||||
| Pathway Interaction Database | N-cadherin signaling events | ||||
| Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Small Ligand GPCRs | |||||
| BDNF signaling pathway | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | A key agonist-induced conformational change in the cannabinoid receptor CB1 is blocked by the allosteric ligand Org 27569. J Biol Chem. 2012 Sep 28;287(40):33873-82. Epub 2012 Jul 30. | ||||
| REF 2 | Indole-2-carboxamides as allosteric modulators of the cannabinoid CB??receptor. J Med Chem. 2012 Jun 14;55(11):5627-31. | ||||
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