| Drug General Information |
| Drug ID |
D05ZGM
|
| Former ID |
DNC004079
|
| Drug Name |
7-Phenoxy-heptanoic acid hydroxyamide
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| Drug Type |
Small molecular drug
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| Indication |
Discovery agent
|
Investigative |
[1]
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| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C13H19NO3
|
| Canonical SMILES |
C1=CC=C(C=C1)OCCCCCCC(=O)NO
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| InChI |
1S/C13H19NO3/c15-13(14-16)10-6-1-2-7-11-17-12-8-4-3-5-9-12/h3-5,8-9,16H,1-2,6-7,10-11H2,(H,14,15)
|
| InChIKey |
IHTQKNINBYXIDN-UHFFFAOYSA-N
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| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Histone deacetylase 1 |
Target Info |
Inhibitor |
[1]
|
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| Histone deacetylase 2 |
Target Info |
Inhibitor |
[1]
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KEGG Pathway
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Cell cycle
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Notch signaling pathway
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Thyroid hormone signaling pathway
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Huntington's disease
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Amphetamine addiction
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Alcoholism
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Epstein-Barr virus infection
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Pathways in cancer
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Transcriptional misregulation in cancer
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Viral carcinogenesis
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MicroRNAs in cancer
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Chronic myeloid leukemiahsa04110:Cell cycle
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Chronic myeloid leukemia
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NetPath Pathway
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TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
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PANTHER Pathway
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Wnt signaling pathway
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p53 pathwayP00057:Wnt signaling pathway
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Pathway Interaction Database
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Regulation of nuclear SMAD2/3 signaling
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Notch signaling pathway
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E2F transcription factor network
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Presenilin action in Notch and Wnt signaling
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Signaling events mediated by HDAC Class I
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Regulation of Telomerase
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Glucocorticoid receptor regulatory network
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Sumoylation by RanBP2 regulates transcriptional repression
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Regulation of Androgen receptor activity
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IL3-mediated signaling events
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Validated nuclear estrogen receptor alpha network
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Retinoic acid receptors-mediated signaling
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Hedgehog signaling events mediated by Gli proteins
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Regulation of nuclear beta catenin signaling and target gene transcription
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Validated targets of C-MYC transcriptional repression
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Regulation of retinoblastoma protein
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Notch-mediated HES/HEY networksmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
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Direct p53 effectors
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Reactome
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G0 and Early G1
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p75NTR negatively regulates cell cycle via SC1
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Formation of the beta-catenin:TCF transactivating complex
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NOTCH1 Intracellular Domain Regulates Transcription
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SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
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Constitutive Signaling by NOTCH1 PEST Domain Mutants
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Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
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HDACs deacetylate histones
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Deactivation of the beta-catenin transactivating complex
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NoRC negatively regulates rRNA expression
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RNA Polymerase I Transcription Initiation
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Factors involved in megakaryocyte development and platelet productionR-HSA-193670:p75NTR negatively regulates cell cycle via SC1
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Factors involved in megakaryocyte development and platelet production
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WikiPathways
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SIDS Susceptibility Pathways
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Notch Signaling Pathway
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TGF beta Signaling Pathway
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IL-6 signaling pathway
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Apoptosis-related network due to altered Notch3 in ovarian cancer
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Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
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Notch Signaling Pathway
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Retinoblastoma (RB) in Cancer
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Neural Crest Differentiation
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TWEAK Signaling Pathway
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Integrated Breast Cancer Pathway
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Signalling by NGF
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RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
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Mitotic G1-G1/S phases
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Factors involved in megakaryocyte development and platelet production
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Cell Cycle
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Androgen receptor signaling pathwayWP61:Notch Signaling Pathway
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| References |
| REF 1 | Bioorg Med Chem Lett. 2003 Nov 3;13(21):3817-20.A novel series of histone deacetylase inhibitors incorporating hetero aromatic ring systems as connection units. |
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