Drug General Information |
Drug ID |
D06SZG
|
Former ID |
DNC012463
|
Drug Name |
6,7-Dichloro-3-hydroxy-1H-quinazoline-2,4-dione
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C8H4Cl2N2O3
|
Canonical SMILES |
C1=C2C(=CC(=C1Cl)Cl)NC(=O)N(C2=O)O
|
InChI |
1S/C8H4Cl2N2O3/c9-4-1-3-6(2-5(4)10)11-8(14)12(15)7(3)13/h1-2,15H,(H,11,14)
|
InChIKey |
URXMQPMLTVUBON-UHFFFAOYSA-N
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PubChem Compound ID |
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Target and Pathway |
Target(s) |
Glutamate [NMDA] receptor subunit epsilon 2 |
Target Info |
Inhibitor |
[1]
|
Glutamate [NMDA] receptor subunit epsilon 1 |
Target Info |
Inhibitor |
[1]
|
NMDA receptor subunit NR1 |
Target Info |
Inhibitor |
[1]
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KEGG Pathway
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Ras signaling pathway
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Rap1 signaling pathway
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cAMP signaling pathway
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Neuroactive ligand-receptor interaction
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Circadian entrainment
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Long-term potentiation
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Glutamatergic synapse
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Dopaminergic synapse
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Alzheimer's disease
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Amyotrophic lateral sclerosis (ALS)
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Huntington's disease
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Cocaine addiction
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Amphetamine addiction
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Nicotine addiction
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Alcoholism
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Systemic lupus erythematosushsa04014:Ras signaling pathway
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Calcium signaling pathway
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PANTHER Pathway
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Huntington disease
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Ionotropic glutamate receptor pathway
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Metabotropic glutamate receptor group III pathway
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Metabotropic glutamate receptor group I pathway
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Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
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Muscarinic acetylcholine receptor 1 and 3 signaling pathway
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Pathway Interaction Database
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ErbB4 signaling events
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Reelin signaling pathwayreelinpathway:Reelin signaling pathway
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Reactome
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EPHB-mediated forward signaling
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Unblocking of NMDA receptor, glutamate binding and activation
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CREB phosphorylation through the activation of CaMKII
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Ras activation uopn Ca2+ infux through NMDA receptor
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RAF/MAP kinase cascadeR-HSA-438066:Unblocking of NMDA receptor, glutamate binding and activation
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RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
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RAF/MAP kinase cascade
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WikiPathways
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Hypothetical Network for Drug Addiction
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Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
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BDNF signaling pathwayWP666:Hypothetical Network for Drug Addiction
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Alzheimers DiseaseWP706:SIDS Susceptibility Pathways
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Spinal Cord Injury
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BDNF signaling pathway
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Alzheimers Disease
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References |
REF 1 | Bioorg Med Chem Lett. 2004 May 3;14(9):2345-9.3-hydroxy-quinazoline-2,4-dione as a useful scaffold to obtain selective Gly/NMDA and AMPA receptor antagonists. |