Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D06UKS
|
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| Former ID |
DIB019244
|
||||
| Drug Name |
compound 14k
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C20H13ClN6
|
||||
| InChI |
InChI=1S/C20H13ClN6/c21-16-6-1-2-7-17(16)25-20-13-8-9-22-10-15(13)12-4-3-5-14(18(12)26-20)19-23-11-24-27-19/h1-11H,(H,25,26)(H,23,24,27)
|
||||
| InChIKey |
WNOHFJIMKSDPHP-UHFFFAOYSA-N
|
||||
| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | FL cytokine receptor | Target Info | Inhibitor | [1] | |
| Serine/threonine-proteinkinase pim-2 | Target Info | Inhibitor | [1] | ||
| casein kinase 1, gamma 3 | Target Info | Inhibitor | [1] | ||
| Proto-oncogene pim-1 | Target Info | Inhibitor | [1] | ||
| PIM-3 protein kinase | Target Info | Inhibitor | [1] | ||
| KEGG Pathway | Cytokine-cytokine receptor interaction | ||||
| Hematopoietic cell lineage | |||||
| Pathways in cancer | |||||
| Transcriptional misregulation in cancer | |||||
| Acute myeloid leukemia | |||||
| Central carbon metabolism in cancerhsa05221:Acute myeloid leukemiahsa04630:Jak-STAT signaling pathway | |||||
| MicroRNAs in cancer | |||||
| NetPath Pathway | IL1 Signaling Pathway | ||||
| TCR Signaling Pathway | |||||
| IL2 Signaling PathwayNetPath_20:IL9 Signaling Pathway | |||||
| IL5 Signaling Pathway | |||||
| IL2 Signaling Pathway | |||||
| TGF_beta_Receptor Signaling Pathway | |||||
| Pathway Interaction Database | GMCSF-mediated signaling events | ||||
| Validated targets of C-MYC transcriptional activation | |||||
| Role of Calcineurin-dependent NFAT signaling in lymphocytes | |||||
| IL5-mediated signaling events | |||||
| IL3-mediated signaling events | |||||
| C-MYB transcription factor network | |||||
| WikiPathways | Hematopoietic Stem Cell DifferentiationWP2858:Ectoderm Differentiation | ||||
| Hematopoietic Stem Cell Differentiation | |||||
| References | |||||
| REF 1 | 7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6687-92. | ||||
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