Drug General Information |
Drug ID |
D07RFM
|
Former ID |
DNC011592
|
Drug Name |
4-[2-(3-Phenyl-propylamino)-ethyl]-phenol
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C17H21NO
|
Canonical SMILES |
C1=CC=C(C=C1)CCCNCCC2=CC=C(C=C2)O
|
InChI |
1S/C17H21NO/c19-17-10-8-16(9-11-17)12-14-18-13-4-7-15-5-2-1-3-6-15/h1-3,5-6,8-11,18-19H,4,7,12-14H2
|
InChIKey |
SJSNYEZWGGSNKY-UHFFFAOYSA-N
|
PubChem Compound ID |
|
Target and Pathway |
Target(s) |
NMDA receptor subunit NR1 |
Target Info |
Inhibitor |
[1]
|
Glutamate [NMDA] receptor subunit epsilon 2 |
Target Info |
Inhibitor |
[1]
|
KEGG Pathway
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Ras signaling pathway
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Rap1 signaling pathway
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Calcium signaling pathway
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cAMP signaling pathway
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Neuroactive ligand-receptor interaction
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Circadian entrainment
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Long-term potentiation
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Glutamatergic synapse
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Alzheimer's disease
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Amyotrophic lateral sclerosis (ALS)
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Huntington's disease
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Cocaine addiction
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Amphetamine addiction
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Nicotine addiction
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Alcoholismhsa04014:Ras signaling pathway
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Dopaminergic synapse
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Alcoholism
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Systemic lupus erythematosus
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PANTHER Pathway
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Huntington disease
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Ionotropic glutamate receptor pathway
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Metabotropic glutamate receptor group III pathway
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Metabotropic glutamate receptor group I pathway
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Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
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Muscarinic acetylcholine receptor 1 and 3 signaling pathway
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Pathway Interaction Database
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ErbB4 signaling events
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Reelin signaling pathway
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Reactome
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EPHB-mediated forward signaling
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Unblocking of NMDA receptor, glutamate binding and activation
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CREB phosphorylation through the activation of CaMKII
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Ras activation uopn Ca2+ infux through NMDA receptor
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RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
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RAF/MAP kinase cascade
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WikiPathways
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SIDS Susceptibility Pathways
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Hypothetical Network for Drug Addiction
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Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
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Spinal Cord Injury
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BDNF signaling pathway
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Alzheimers DiseaseWP666:Hypothetical Network for Drug Addiction
|
References |
REF 1 | J Med Chem. 1998 Aug 27;41(18):3499-506.Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors. |