Drug Information
Drug General Information | |||||
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Drug ID |
D07VEB
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Former ID |
DIB019477
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Drug Name |
compound 3h
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [1], [2] | ||
Structure |
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Download2D MOL |
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Formula |
C27H28BrF2NO4
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InChI |
InChI=1S/C27H28BrF2NO4/c1-16(2)26-25(28)24(17-4-8-19(29)9-5-17)27(18-6-10-20(30)11-7-18)31(26)13-12-21(32)14-22(33)15-23(34)35-3/h4-13,16,21-22,32-33H,14-15H2,1-3H3/b13-12+/t21-,22-/m1/s1
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InChIKey |
MUTCAPXLKRYEPR-ITWZMISCSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Target Info | Inhibitor | [1] | |
BioCyc Pathway | Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) | ||||
Superpathway of cholesterol biosynthesis | |||||
Mevalonate pathway | |||||
KEGG Pathway | Terpenoid backbone biosynthesis | ||||
Metabolic pathways | |||||
Biosynthesis of antibiotics | |||||
AMPK signaling pathway | |||||
Bile secretion | |||||
NetPath Pathway | IL5 Signaling Pathway | ||||
TGF_beta_Receptor Signaling Pathway | |||||
TSH Signaling Pathway | |||||
PANTHER Pathway | Cholesterol biosynthesis | ||||
PathWhiz Pathway | Steroid Biosynthesis | ||||
WikiPathways | Statin Pathway | ||||
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | |||||
Activation of Gene Expression by SREBP (SREBF) | |||||
SREBF and miR33 in cholesterol and lipid homeostasis | |||||
Integrated Breast Cancer Pathway | |||||
SREBP signalling | |||||
Cholesterol Biosynthesis | |||||
References | |||||
REF 1 | Inhibitors of cholesterol biosynthesis. 2. 3,5-Dihydroxy-7-(N-pyrrolyl)-6-heptenoates, a novel series of HMG-CoA reductase inhibitors. J Med Chem. 1993 Nov 12;36(23):3658-62. | ||||
REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2956). | ||||
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