Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D08CMW
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| Former ID |
DNC012193
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| Drug Name |
6-Phenylaminomethyl-quinazoline-2,4-diamine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C15H15N5
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| Canonical SMILES |
C1=CC=C(C=C1)NCC2=CC3=C(C=C2)N=C(N=C3N)N
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| InChI |
1S/C15H15N5/c16-14-12-8-10(6-7-13(12)19-15(17)20-14)9-18-11-4-2-1-3-5-11/h1-8,18H,9H2,(H4,16,17,19,20)
|
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| InChIKey |
SQHNSLWKFCXHKZ-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Dihydrofolate reductase | Target Info | Inhibitor | [1] | |
| PathWhiz Pathway | Folate Metabolism | ||||
| Pterine Biosynthesis | |||||
| Reactome | E2F mediated regulation of DNA replication | ||||
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | |||||
| Metabolism of folate and pterines | |||||
| G1/S-Specific Transcription | |||||
| References | |||||
| REF 1 | J Med Chem. 2003 Jul 31;46(16):3455-62.Design and synthesis of dihydrofolate reductase inhibitors encompassing a bridging ester group. Evaluation in a mouse colitis model. | ||||
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