| Drug General Information |
| Drug ID |
D08CZD
|
| Former ID |
DNC003443
|
| Drug Name |
4-(2-methoxyethoxy)-6-methylpyrimidin-2-amine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C8H13N3O2
|
| Canonical SMILES |
CC1=CC(=NC(=N1)N)OCCOC
|
| InChI |
1S/C8H13N3O2/c1-6-5-7(11-8(9)10-6)13-4-3-12-2/h5H,3-4H2,1-2H3,(H2,9,10,11)
|
| InChIKey |
VCJHOFUOIQHNBC-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
5346725, 41628588, 76235672, 84981717, 85266844, 99445257, 103689250, 112177136, 123070118, 126310137, 129454809, 162103402, 170481474, 212528998, 224820753, 236010271, 249554296
|
| Target and Pathway |
| Target(s) |
Heat shock protein HSP 90 |
Target Info |
Inhibitor |
[1]
|
|---|
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KEGG Pathway
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Protein processing in endoplasmic reticulum
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PI3K-Akt signaling pathway
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Antigen processing and presentation
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NOD-like receptor signaling pathway
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Progesterone-mediated oocyte maturation
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Estrogen signaling pathway
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Pathways in cancer
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Prostate cancer
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NetPath Pathway
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IL2 Signaling Pathway
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TCR Signaling Pathway
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Pathway Interaction Database
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Signaling events mediated by HDAC Class II
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Validated targets of C-MYC transcriptional activation
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Integrin-linked kinase signaling
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LKB1 signaling events
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Regulation of Telomerase
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Glucocorticoid receptor regulatory network
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Class I PI3K signaling events
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IL2 signaling events mediated by PI3K
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Regulation of Androgen receptor activity
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Integrins in angiogenesis
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Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
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ErbB receptor signaling network
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VEGFR1 specific signals
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Signaling events mediated by VEGFR1 and VEGFR2
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Class I PI3K signaling events mediated by Akt
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Reactome
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Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
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Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
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Regulation of actin dynamics for phagocytic cup formation
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eNOS activation
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Regulation of PLK1 Activity at G2/M Transition
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Attenuation phase
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HSF1-dependent transactivation
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Loss of Nlp from mitotic centrosomes
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Recruitment of mitotic centrosome proteins and complexes
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Loss of proteins required for interphase microtubule organization?from the centrosome
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EPHA-mediated growth cone collapse
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VEGFA-VEGFR2 Pathway
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VEGFR2 mediated vascular permeability
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Anchoring of the basal body to the plasma membrane
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Constitutive Signaling by EGFRvIII
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WikiPathways
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NRF2 pathway
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Nuclear Receptors Meta-Pathway
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Aryl Hydrocarbon Receptor Pathway
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Binding and Uptake of Ligands by Scavenger Receptors
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Signaling by ERBB2
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Fcgamma receptor (FCGR) dependent phagocytosis
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Influenza Life Cycle
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EBV LMP1 signaling
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Aryl Hydrocarbon Receptor
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Corticotropin-releasing hormone
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TNF alpha Signaling Pathway
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Arylhydrocarbon receptor (AhR) signaling pathway
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Signaling by EGFR
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Semaphorin interactions
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Mitotic G2-G2/M phases
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Metabolism of nitric oxide
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NOD pathway
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| References |
| REF 1 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. |
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