Drug Information
Drug General Information | |||||
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Drug ID |
D08HIH
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Former ID |
DIB001036
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Drug Name |
ERB-196
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Synonyms |
WAY-196; WAY-202196; Estrogen receptor beta agonist (oral, inflammation/sepsis), Wyeth
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Indication | Inflammatory bowel disease [ICD9: 555, 556; ICD10:K50, K51] | Discontinued in Phase 1 | [1] | ||
Company |
Wyeth
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Structure |
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Download2D MOL |
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Canonical SMILES |
c1(c2c(cc(c3cc(c(cc3)O)F)c1)ccc(c2)O)C#N
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CAS Number |
CAS 550997-55-2
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Target and Pathway | |||||
Target(s) | Estrogen receptor beta | Target Info | Agonist | [2] | |
KEGG Pathway | Estrogen signaling pathway | ||||
Prolactin signaling pathway | |||||
Pathway Interaction Database | Plasma membrane estrogen receptor signaling | ||||
Validated nuclear estrogen receptor beta network | |||||
Validated nuclear estrogen receptor alpha network | |||||
Reactome | Nuclear Receptor transcription pathway | ||||
WikiPathways | SIDS Susceptibility Pathways | ||||
Ovarian Infertility Genes | |||||
Integrated Pancreatic Cancer Pathway | |||||
Nuclear Receptors | |||||
References | |||||
REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021229) | ||||
REF 2 | WAY-202196, a selective estrogen receptor-beta agonist, protects against death in experimental septic shock. Crit Care Med. 2006 Aug;34(8):2188-93. | ||||
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