Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D08MLH
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| Former ID |
DIB009237
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| Drug Name |
TUG-469
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| Synonyms |
Free fatty acid receptor 1 agonist (type 2 diabetes), University of Souther Denmark
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| Indication | Non-insulin dependent diabetes [ICD10:E11.9] | Investigative | [1] | ||
| Company |
University of Southern Denmark
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
c1ccc(c(c1)C)c1cccc(c1)CNc1ccc(cc1)CCC(=O)O
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| Target and Pathway | |||||
| Target(s) | GPR40 | Target Info | Agonist | [1] | |
| KEGG Pathway | Insulin secretion | ||||
| Reactome | G alpha (q) signalling events | ||||
| Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Incretin Synthesis, Secretion, and Inactivation | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Integration of energy metabolism | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 225). | ||||
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