| Drug General Information |
| Drug ID |
D08SIJ
|
| Former ID |
DNC009578
|
| Drug Name |
1,1,1-Trifluoro-4-(4-hexyloxy-phenyl)-butan-2-one
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C16H21F3O2
|
| Canonical SMILES |
CCCCCCOC1=CC=C(C=C1)CCC(=O)C(F)(F)F
|
| InChI |
1S/C16H21F3O2/c1-2-3-4-5-12-21-14-9-6-13(7-10-14)8-11-15(20)16(17,18)19/h6-7,9-10H,2-5,8,11-12H2,1H3
|
| InChIKey |
UOOMUFUVLSIOFF-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Cytosolic phospholipase A2 |
Target Info |
Inhibitor |
[1]
|
|---|
|
BioCyc Pathway
|
Phospholipases
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KEGG Pathway
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Glycerophospholipid metabolism
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Ether lipid metabolism
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Arachidonic acid metabolism
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Linoleic acid metabolism
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alpha-Linolenic acid metabolism
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Metabolic pathways
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MAPK signaling pathway
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Ras signaling pathway
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Vascular smooth muscle contraction
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VEGF signaling pathway
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Platelet activation
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Fc epsilon RI signaling pathway
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Fc gamma R-mediated phagocytosis
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Glutamatergic synapse
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Serotonergic synapse
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Long-term depression
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Inflammatory mediator regulation of TRP channels
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GnRH signaling pathway
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Ovarian steroidogenesis
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Oxytocin signaling pathway
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Choline metabolism in cancer
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NetPath Pathway
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TCR Signaling Pathway
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PANTHER Pathway
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Angiogenesis
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Endothelin signaling pathway
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Inflammation mediated by chemokine and cytokine signaling pathway
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Oxidative stress response
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VEGF signaling pathway
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CCKR signaling map ST
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Pathway Interaction Database
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Fc-epsilon receptor I signaling in mast cells
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Endothelins
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PDGFR-beta signaling pathway
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Signaling mediated by p38-alpha and p38-beta
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PathWhiz Pathway
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Fc Epsilon Receptor I Signaling in Mast Cells
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Reactome
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Acyl chain remodelling of PC
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Acyl chain remodelling of PE
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Acyl chain remodelling of PI
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ADP signalling through P2Y purinoceptor 1
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Platelet sensitization by LDL
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WikiPathways
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Prostaglandin Synthesis and Regulation
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p38 MAPK Signaling Pathway
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Glycerophospholipid biosynthesis
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Arachidonic acid metabolism
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PDGF Pathway
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Integrated Pancreatic Cancer Pathway
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AGE/RAGE pathway
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Opioid Signalling
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Signal amplification
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Platelet homeostasis
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| References |
| REF 1 | J Med Chem. 2008 Dec 25;51(24):8027-37.Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes. |
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