Drug General Information |
Drug ID |
D09BZV
|
Former ID |
DNC011570
|
Drug Name |
4-[2-(4-Benzyl-piperidin-1-yl)-ethoxy]-phenol
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C20H25NO2
|
Canonical SMILES |
C1CN(CCC1CC2=CC=CC=C2)CCOC3=CC=C(C=C3)O
|
InChI |
1S/C20H25NO2/c22-19-6-8-20(9-7-19)23-15-14-21-12-10-18(11-13-21)16-17-4-2-1-3-5-17/h1-9,18,22H,10-16H2
|
InChIKey |
CSOKNRXDEKJUFZ-UHFFFAOYSA-N
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PubChem Compound ID |
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Target and Pathway |
Target(s) |
Glutamate [NMDA] receptor subunit epsilon 2 |
Target Info |
Inhibitor |
[1]
|
NMDA receptor subunit NR1 |
Target Info |
Inhibitor |
[1]
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KEGG Pathway
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Ras signaling pathway
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Rap1 signaling pathway
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cAMP signaling pathway
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Neuroactive ligand-receptor interaction
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Circadian entrainment
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Long-term potentiation
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Glutamatergic synapse
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Dopaminergic synapse
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Alzheimer's disease
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Amyotrophic lateral sclerosis (ALS)
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Huntington's disease
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Cocaine addiction
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Amphetamine addiction
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Nicotine addiction
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Alcoholism
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Systemic lupus erythematosushsa04014:Ras signaling pathway
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Calcium signaling pathway
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PANTHER Pathway
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Huntington disease
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Ionotropic glutamate receptor pathway
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Metabotropic glutamate receptor group III pathway
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Metabotropic glutamate receptor group I pathway
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Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
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Muscarinic acetylcholine receptor 1 and 3 signaling pathway
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Pathway Interaction Database
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ErbB4 signaling events
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Reelin signaling pathway
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Reactome
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EPHB-mediated forward signaling
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Unblocking of NMDA receptor, glutamate binding and activation
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CREB phosphorylation through the activation of CaMKII
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Ras activation uopn Ca2+ infux through NMDA receptor
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RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
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RAF/MAP kinase cascade
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WikiPathways
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Hypothetical Network for Drug Addiction
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Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
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BDNF signaling pathwayWP706:SIDS Susceptibility Pathways
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Spinal Cord Injury
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BDNF signaling pathway
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Alzheimers Disease
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References |
REF 1 | J Med Chem. 1999 Jul 29;42(15):2993-3000.4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel, potent, and selective NR1/2B NMDA receptor antagonist. |