| Drug General Information |
| Drug ID |
D0B3ZB
|
| Former ID |
DIB019952
|
| Drug Name |
indirubin deriv. 8a
|
| Synonyms |
indirubin deriv. 8a
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C18H12BrN3O3
|
| InChI |
InChI=1S/C18H12BrN3O3/c1-9(23)25-22-16-12-4-2-3-5-13(12)20-17(16)15-11-7-6-10(19)8-14(11)21-18(15)24/h2-8,22H,1H3,(H,21,24)/b17-15-
|
| InChIKey |
ORWSYHWTBSHFIV-ICFOKQHNSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
11108193, 16441663, 16477946, 26758804, 43184037, 47425345, 50352578, 99302719, 103029102, 103567181, 114614451, 135698764, 163336448, 163688039, 175607481, 178102598, 180407000, 204379269, 208265530, 223704948
|
| Target and Pathway |
| Target(s) |
mRNA of human glycogen synthase kinase 3 alpha |
Target Info |
Inhibitor |
[1]
|
|---|
| Glycogen synthase kinase-3 beta |
Target Info |
Inhibitor |
[1]
|
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KEGG Pathway
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Chemokine signaling pathway
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Dopaminergic synapse
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Non-alcoholic fatty liver disease (NAFLD)hsa04012:ErbB signaling pathway
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Cell cycle
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PI3K-Akt signaling pathway
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Wnt signaling pathway
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Hedgehog signaling pathway
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Axon guidance
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Hippo signaling pathway
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Focal adhesion
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Signaling pathways regulating pluripotency of stem cells
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T cell receptor signaling pathway
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B cell receptor signaling pathway
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Neurotrophin signaling pathway
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Insulin signaling pathway
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Melanogenesis
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Prolactin signaling pathway
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Thyroid hormone signaling pathway
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Non-alcoholic fatty liver disease (NAFLD)
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Alzheimer's disease
|
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Hepatitis C
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Measles
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Influenza A
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HTLV-I infection
|
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Epstein-Barr virus infection
|
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Pathways in cancer
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Colorectal cancer
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Endometrial cancer
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Prostate cancer
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Basal cell carcinoma
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NetPath Pathway
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TGF_beta_Receptor Signaling Pathway
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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Insulin/IGF pathway-protein kinase B signaling cascade
|
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PDGF signaling pathway
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Ras PathwayP00004:Alzheimer disease-presenilin pathway
|
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Angiogenesis
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Cadherin signaling pathway
|
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Hedgehog signaling pathway
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Interleukin signaling pathway
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PI3 kinase pathway
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Wnt signaling pathway
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Ras Pathway
|
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CCKR signaling map ST
|
|
Pathway Interaction Database
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Degradation of beta catenin
|
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Canonical Wnt signaling pathway
|
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FOXM1 transcription factor network
|
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Class I PI3K signaling events mediated by Aktlysophospholipid_pathway:LPA receptor mediated events
|
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Reelin signaling pathway
|
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Presenilin action in Notch and Wnt signaling
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Integrin-linked kinase signaling
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CDC42 signaling events
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LKB1 signaling events
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Role of Calcineurin-dependent NFAT signaling in lymphocytes
|
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Glucocorticoid receptor regulatory network
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C-MYC pathway
|
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Regulation of Androgen receptor activity
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BMP receptor signaling
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Hedgehog signaling events mediated by Gli proteins
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Signaling events mediated by Stem cell factor receptor (c-Kit)
|
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Validated transcriptional targets of deltaNp63 isoforms
|
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Aurora A signaling
|
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Insulin-mediated glucose transport
|
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Class I PI3K signaling events mediated by Akt
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p53 pathway
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Trk receptor signaling mediated by PI3K and PLC-gamma
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Reactome
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AKT phosphorylates targets in the cytosol
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XBP1(S) activates chaperone genes
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Constitutive Signaling by AKT1 E17K in CancerR-HSA-195253:Degradation of beta-catenin by the destruction complex
|
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Regulation of HSF1-mediated heat shock response
|
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CRMPs in Sema3A signaling
|
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Disassembly of the destruction complex and recruitment of AXIN to the membrane
|
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S33 mutants of beta-catenin aren't phosphorylated
|
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S37 mutants of beta-catenin aren't phosphorylated
|
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S45 mutants of beta-catenin aren't phosphorylated
|
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T41 mutants of beta-catenin aren't phosphorylated
|
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Degradation of GLI2 by the proteasome
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Constitutive Signaling by AKT1 E17K in Cancer
|
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WikiPathways
|
Glycogen Metabolism
|
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Insulin Signaling
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Wnt Signaling Pathway Netpath
|
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Activation of Chaperone Genes by XBP1(S)
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T-Cell Receptor and Co-stimulatory Signaling
|
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Integrated Pancreatic Cancer Pathway
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B Cell Receptor Signaling Pathway
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Leptin signaling pathway
|
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Integrated Breast Cancer Pathway
|
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SREBP signalling
|
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IL-5 Signaling PathwayWP710:DNA Damage Response (only ATM dependent)
|
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Senescence and Autophagy in Cancer
|
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Notch Signaling Pathway
|
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Wnt Signaling Pathway
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Wnt Signaling Pathway and Pluripotency
|
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IL-6 signaling pathway
|
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Copper homeostasis
|
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Focal Adhesion
|
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Hair Follicle Development: Induction (Part 1 of 3)
|
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Cardiac Hypertrophic Response
|
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Degradation of beta-catenin by the destruction complex
|
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Cardiac Progenitor Differentiation
|
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BDNF signaling pathway
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Corticotropin-releasing hormone
|
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IL17 signaling pathway
|
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Neural Crest Differentiation
|
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Alzheimers Disease
|
|
IL-7 Signaling Pathway
|
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Regulation of Microtubule Cytoskeleton
|
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TWEAK Signaling Pathway
|
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Semaphorin interactions
|
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Cell Cycle
|
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MicroRNAs in cardiomyocyte hypertrophy
|
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Androgen receptor signaling pathway
|
|
IL-5 Signaling Pathway
|
| References |
| REF 1 | Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J Med Chem. 2004 Feb 12;47(4):935-46. |
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