Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0BY6E
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| Former ID |
DNC013099
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| Drug Name |
4-hydroxy-8-nitro-3-phenylquinolin-2(1H)-one
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C15H10N2O4
|
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| Canonical SMILES |
C1=CC=C(C=C1)C2=C(C3=C(C(=CC=C3)[N+](=O)[O-])NC2=O)O
|
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| InChI |
1S/C15H10N2O4/c18-14-10-7-4-8-11(17(20)21)13(10)16-15(19)12(14)9-5-2-1-3-6-9/h1-8H,(H2,16,18,19)
|
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| InChIKey |
XWRIMEVQDODFAZ-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Fatty acid synthase | Target Info | Inhibitor | [1] | |
| BioCyc Pathway | Fatty acid biosynthesis initiation | ||||
| Fatty acid elongation -- saturated | |||||
| Palmitate biosynthesis | |||||
| KEGG Pathway | Fatty acid biosynthesis | ||||
| Metabolic pathways | |||||
| Fatty acid metabolism | |||||
| AMPK signaling pathway | |||||
| Insulin signaling pathway | |||||
| Pathway Interaction Database | p73 transcription factor network | ||||
| Validated transcriptional targets of deltaNp63 isoforms | |||||
| PathWhiz Pathway | Fatty Acid Biosynthesis | ||||
| Reactome | ChREBP activates metabolic gene expression | ||||
| Activation of gene expression by SREBF (SREBP) | |||||
| Fatty Acyl-CoA Biosynthesis | |||||
| WikiPathways | Fatty Acid Biosynthesis | ||||
| Nuclear Receptors Meta-Pathway | |||||
| Liver X Receptor Pathway | |||||
| Activation of Gene Expression by SREBP (SREBF) | |||||
| SREBF and miR33 in cholesterol and lipid homeostasis | |||||
| SREBP signalling | |||||
| Metabolism of water-soluble vitamins and cofactors | |||||
| Integration of energy metabolism | |||||
| Fatty acid, triacylglycerol, and ketone body metabolism | |||||
| AMPK Signaling | |||||
| References | |||||
| REF 1 | Bioorg Med Chem Lett. 2006 Sep 1;16(17):4620-3. Epub 2006 Jun 19.3-Aryl-4-hydroxyquinolin-2(1H)-one derivatives as type I fatty acid synthase inhibitors. | ||||
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