Drug General Information
Drug ID	D0CV7T
Former ID	DIB015873
Drug Name	Patamostat
Synonyms	E-3123
Drug Type	Small molecular drug
Indication	Hypotension [ICD9: 458, 796.3; ICD10:I95]		Terminated	[1]
Company	Eisai Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C20H20N4O4S
Canonical SMILES	N1(C(=O)CCC1=O)CCSc1ccc(OC(=O)c2ccc(NC(=N)N)cc2)cc1.S(=<br />O)(=O)(O)C
CAS Number	CAS 114568-32-0
PubChem Compound ID	65921
Target and Pathway
Target(s)	Trypsin	Target Info	Modulator	[2], [3], [4]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Pancreatic secretion
	Protein digestion and absorption
	Influenza A
Reactome	Activation of Matrix Metalloproteinases
	Cobalamin (Cbl, vitamin B12) transport and metabolism
WikiPathways	Activation of Matrix Metalloproteinases
References
REF 1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003114)
REF 2	Effects of E-3123, a new protease inhibitor, on several protease activities and on experimental acute pancreatitis. Nihon Yakurigaku Zasshi. 1988 May;91(5):285-93.
REF 3	US patent application no. 2012,0251,516, PHARMACEUTICAL COMPOSITION FOR TREATING CANCER COMPRISING TRYPSINOGEN AND/OR CHYMOTRYPSINOGEN AND AN ACTIVE AGENT SELECTED FROM A SELENIUM COMPOUND, A VANILLOID COMPOUND AND A CYTOPLASMIC GLYCOLYSIS REDUCTION AGENT.
REF 4	EP patent application no. 2490711, A pharmaceutical composition for treating cancer comprising trypsinogen and/or chymotrypsinogen and an active agent selected from a selenium compound, a vanilloid compound and a cytoplasmic glycolysis reduction agent).

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