Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0D6DH
|
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| Former ID |
DNC006034
|
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| Drug Name |
A-432411
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C20H16N2O3
|
||||
| Canonical SMILES |
COC1=C(C=CC(=C1)C2=CC3=C(C=C2)C(=CC4=CC=CN4)C(=O)N3)O
|
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| InChI |
1S/C20H16N2O3/c1-25-19-10-13(5-7-18(19)23)12-4-6-15-16(11-14-3-2-8-21-14)20(24)22-17(15)9-12/h2-11,21,23H,1H3,(H,22,24)/b16-11-
|
||||
| InChIKey |
AYSXURJZVXBSRV-WJDWOHSUSA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Serine/threonine-protein kinase Chk1 | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Cell cycle | ||||
| p53 signaling pathway | |||||
| HTLV-I infection | |||||
| Viral carcinogenesis | |||||
| Pathway Interaction Database | Fanconi anemia pathway | ||||
| p73 transcription factor network | |||||
| ATR signaling pathway | |||||
| Circadian rhythm pathway | |||||
| p53 pathway | |||||
| Reactome | Activation of ATR in response to replication stress | ||||
| Processing of DNA double-strand break ends | |||||
| Presynaptic phase of homologous DNA pairing and strand exchange | |||||
| G2/M DNA damage checkpoint | |||||
| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | |||||
| Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | |||||
| WikiPathways | DNA Damage Response | ||||
| Signaling by SCF-KIT | |||||
| ATM Signaling Pathway | |||||
| Retinoblastoma (RB) in Cancer | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Prostate Cancer | |||||
| Integrated Breast Cancer Pathway | |||||
| Integrated Cancer pathway | |||||
| Cell Cycle | |||||
| Cell Cycle Checkpoints | |||||
| miRNA Regulation of DNA Damage Response | |||||
| References | |||||
| REF 1 | Bioorg Med Chem Lett. 2010 Sep 1;20(17):5065-8. Epub 2010 Jul 13.Synthesis of selenophene derivatives as novel CHK1 inhibitors. | ||||
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