| Drug General Information |
| Drug ID |
D0G6UQ
|
| Former ID |
DIB008183
|
| Drug Name |
EP-42675
|
| Synonyms |
NAPAP analogs, Organon; Factor IIa/Factor X dual inhibitors (thrombosis), Endotis; Factor IIa/Factor X dual inhibitors (thrombosis), Organon; NAPAP-PS conjugate (thrombosis), Endotis; NAPAP-PS conjugate (thrombosis), Organon
|
| Indication |
Thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82]
|
Phase 1 |
[1]
|
|---|
| Company |
Organon BioSciences
|
| Structure |
|
Download
2D MOL
3D MOL
|
| Canonical SMILES |
[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].O(S(=O)<br />(=O)[O-])[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1O[C@@H]1[C@@<br />H](O[C@H]([C@@H]([C@H]1OC)OC)O[C@H]1[C@@H]([C@H]([C@H](<br />O[C@@H]1COS(=O)(=O)[O-])OC)OS(=O)(=O)[O-])OC)C(=O)[O-])<br />COS(=O)(=O)[O-])O[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1OC)O<br />C)O[C@@H]1[C@@H]([C@H]([C@@H]([C@H](O1)COS(=O)(=O)[O-])<br />OCCOCCOCCOCCNC(=O)CCCNC(=O)C[C@H](NS(=O)(=O)c1c(c(c(cc1<br />C)OC)C)C)C(=O)N[C@@H](C(=O)N1CCCCC1)Cc1ccc(C(=N)N)cc1)O<br />C)OC)C(=O)[O-])OS(=O)(=O)[O-]
|
| Target and Pathway |
| Target(s) |
Coagulation factor Xa |
Target Info |
Modulator |
[2]
|
|---|
| Coagulation factor IIa |
Target Info |
Modulator |
[2]
|
|
KEGG Pathway
|
Complement and coagulation cascadeshsa04080:Neuroactive ligand-receptor interaction
|
|
Complement and coagulation cascades
|
|
Regulation of actin cytoskeleton
|
|
NetPath Pathway
|
TCR Signaling Pathway
|
|
PANTHER Pathway
|
Blood coagulationP00011:Blood coagulation
|
|
Pathway Interaction Database
|
Beta2 integrin cell surface interactionsthrombin_pathway:Thrombin/protease-activated receptor (PAR) pathway
|
|
Angiopoietin receptor Tie2-mediated signaling
|
|
FOXA2 and FOXA3 transcription factor networks
|
|
PAR4-mediated thrombin signaling events
|
|
Syndecan-4-mediated signaling events
|
|
PAR1-mediated thrombin signaling events
|
|
PathWhiz Pathway
|
CoagulationPW000047:Vitamin K Metabolism
|
|
Coagulation
|
|
Reactome
|
Extrinsic Pathway of Fibrin Clot Formation
|
|
Intrinsic Pathway of Fibrin Clot Formation
|
|
Common Pathway of Fibrin Clot Formation
|
|
Gamma-carboxylation of protein precursors
|
|
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
|
|
Removal of aminoterminal propeptides from gamma-carboxylated proteinsR-HSA-140837:Intrinsic Pathway of Fibrin Clot Formation
|
|
Removal of aminoterminal propeptides from gamma-carboxylated proteins
|
|
Cell surface interactions at the vascular wall
|
|
Peptide ligand-binding receptors
|
|
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
|
|
G alpha (q) signalling events
|
|
Thrombin signalling through proteinase activated receptors (PARs)
|
|
WikiPathways
|
Complement and Coagulation Cascades
|
|
Human Complement System
|
|
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
|
|
Blood Clotting Cascade
|
|
Formation of Fibrin Clot (Clotting Cascade)WP558:Complement and Coagulation Cascades
|
|
Regulation of Actin Cytoskeleton
|
|
IL1 and megakaryotyces in obesity
|
|
Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
|
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
|
Thrombin signalling through proteinase activated receptors (PARs)
|
|
Platelet Aggregation (Plug Formation)
|
|
GPCR ligand binding
|
|
GPCR downstream signaling
|
|
Formation of Fibrin Clot (Clotting Cascade)
|
|
Cell surface interactions at the vascular wall
|
|
Folate Metabolism
|
|
Vitamin B12 Metabolism
|
|
Selenium Micronutrient Network
|
| References |
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023539) |
|---|
| REF 2 | EP42675, a synthetic parenteral dual-action anticoagulant: pharmacokinetics, pharmacodynamics, and absence of interactions with antiplatelet drugs. J Thromb Haemost. 2014 Jan;12(1):24-33. |
|---|
