Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0JA3Y
|
||||
| Former ID |
DCL001212
|
||||
| Drug Name |
MEDI-578
|
||||
| Indication | Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] | Phase 1 | [551134] | ||
| Target and Pathway | |||||
| Target(s) | Beta-nerve growth factor | Target Info | Modulator | ||
| Reactome | Frs2-mediated activation | ||||
| ARMS-mediated activation | |||||
| NRAGE signals death through JNK | |||||
| p75NTR negatively regulates cell cycle via SC1 | |||||
| PI3K/AKT activation | |||||
| NADE modulates death signalling | |||||
| NRIF signals cell death from the nucleus | |||||
| p75NTR recruits signalling complexes | |||||
| NF-kB is activated and signals survival | |||||
| Axonal growth stimulation | |||||
| References | |||||
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