Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0K8VR
|
||||
| Former ID |
DIB018307
|
||||
| Drug Name |
[3H]HU-243
|
||||
| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C25H40O3
|
||||
| InChI |
InChI=1S/C25H40O3/c1-6-7-8-9-12-24(2,3)18-14-21(27)23-19-13-17(16-26)10-11-20(19)25(4,5)28-22(23)15-18/h14-15,17,19-20,26-27H,6-13,16H2,1-5H3/t17-,19-,20-/m1/s1/i10T,17T/t10?,17-,19-,20-
|
||||
| InChIKey |
MVEVPDCVOXJVBD-AENGYHINSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Cannabinoid receptor 1 | Target Info | Agonist | [2] | |
| Cannabinoid receptor 2 | Target Info | Agonist | [3] | ||
| KEGG Pathway | Rap1 signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Retrograde endocannabinoid signalinghsa04080:Neuroactive ligand-receptor interaction | |||||
| PANTHER Pathway | Endogenous cannabinoid signaling | ||||
| Pathway Interaction Database | N-cadherin signaling events | ||||
| Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
| G alpha (i) signalling eventsR-HSA-373076:Class A/1 (Rhodopsin-like receptors) | |||||
| G alpha (i) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Small Ligand GPCRs | |||||
| BDNF signaling pathway | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 735). | ||||
| REF 2 | A novel probe for the cannabinoid receptor. J Med Chem. 1992 May 29;35(11):2065-9. | ||||
| REF 3 | The peripheral cannabinoid receptor: adenylate cyclase inhibition and G protein coupling. FEBS Lett. 1995 Nov 13;375(1-2):143-7. | ||||
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