| Drug General Information |
| Drug ID |
D0L5DZ
|
| Former ID |
DPR000166
|
| Drug Name |
4SC-202
|
| Indication |
Cancer [ICD9: 140-229; ICD10:C00-C96]
|
Preclinical |
[1]
|
|---|
| Company |
4SC AG
|
| Structure |
|
Download
2D MOL
|
| Target and Pathway |
| Target(s) |
Histone deacetylase 1 |
Target Info |
Inhibitor |
[1]
|
|---|
|
KEGG Pathway
|
Cell cycle
|
|
Notch signaling pathway
|
|
Thyroid hormone signaling pathway
|
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Huntington's disease
|
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Amphetamine addiction
|
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Alcoholism
|
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Epstein-Barr virus infection
|
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Pathways in cancer
|
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Transcriptional misregulation in cancer
|
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Viral carcinogenesis
|
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MicroRNAs in cancer
|
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Chronic myeloid leukemia
|
|
NetPath Pathway
|
TCR Signaling Pathway
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PANTHER Pathway
|
Wnt signaling pathway
|
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p53 pathway
|
|
Pathway Interaction Database
|
Regulation of nuclear SMAD2/3 signaling
|
|
Notch signaling pathway
|
|
E2F transcription factor network
|
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Presenilin action in Notch and Wnt signaling
|
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Signaling events mediated by HDAC Class I
|
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Regulation of Telomerase
|
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Glucocorticoid receptor regulatory network
|
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Sumoylation by RanBP2 regulates transcriptional repression
|
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Regulation of Androgen receptor activity
|
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IL3-mediated signaling events
|
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Validated nuclear estrogen receptor alpha network
|
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Retinoic acid receptors-mediated signaling
|
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Hedgehog signaling events mediated by Gli proteins
|
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Regulation of nuclear beta catenin signaling and target gene transcription
|
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Validated targets of C-MYC transcriptional repression
|
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Regulation of retinoblastoma protein
|
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Notch-mediated HES/HEY network
|
|
Reactome
|
G0 and Early G1
|
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p75NTR negatively regulates cell cycle via SC1
|
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Formation of the beta-catenin:TCF transactivating complex
|
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NOTCH1 Intracellular Domain Regulates Transcription
|
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SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
|
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Constitutive Signaling by NOTCH1 PEST Domain Mutants
|
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Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
|
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HDACs deacetylate histones
|
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Deactivation of the beta-catenin transactivating complex
|
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NoRC negatively regulates rRNA expression
|
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RNA Polymerase I Transcription Initiation
|
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Factors involved in megakaryocyte development and platelet production
|
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WikiPathways
|
SIDS Susceptibility Pathways
|
|
Notch Signaling Pathway
|
|
TGF beta Signaling Pathway
|
|
IL-6 signaling pathway
|
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Apoptosis-related network due to altered Notch3 in ovarian cancer
|
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Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
|
|
Notch Signaling Pathway
|
|
Retinoblastoma (RB) in Cancer
|
|
Neural Crest Differentiation
|
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TWEAK Signaling Pathway
|
|
Integrated Breast Cancer Pathway
|
|
Signalling by NGF
|
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RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
|
|
Mitotic G1-G1/S phases
|
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Factors involved in megakaryocyte development and platelet production
|
|
Cell Cycle
|
|
Androgen receptor signaling pathway
|
| References |
| REF 1 | 2011 Pipeline of 4SC AG. |
|---|
