Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0P8QN
|
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| Former ID |
DIB010807
|
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| Drug Name |
Recombinant Factor IX
|
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| Synonyms |
RFIX, Baxter; Recombinant Factor IX, Baxter
|
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| Indication | Factor IX deficiency [ICD10:D67] | Terminated | [1] | ||
| Company |
Baxter 1nternational
|
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| Target and Pathway | |||||
| Target(s) | Coagulation factor IX | Target Info | Modulator | [2] | |
| KEGG Pathway | Complement and coagulation cascades | ||||
| PANTHER Pathway | Blood coagulation | ||||
| PathWhiz Pathway | Coagulation | ||||
| Reactome | Extrinsic Pathway of Fibrin Clot Formation | ||||
| Intrinsic Pathway of Fibrin Clot Formation | |||||
| Gamma-carboxylation of protein precursors | |||||
| Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus | |||||
| Removal of aminoterminal propeptides from gamma-carboxylated proteins | |||||
| WikiPathways | Complement and Coagulation Cascades | ||||
| PTM: gamma carboxylation, hypusine formation and arylsulfatase activation | |||||
| Blood Clotting Cascade | |||||
| Formation of Fibrin Clot (Clotting Cascade) | |||||
| References | |||||
| REF 1 | Clinical pipeline report, company report or official report of Baxter 1nternational. | ||||
| REF 2 | BAX326 (RIXUBIS): a novel recombinant factor IX for the control and prevention of bleeding episodes in adults and children with hemophilia B. Ther Adv Hematol. 2014 Oct;5(5):168-80. | ||||
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