Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0Q2EH
|
||||
| Former ID |
DIB004656
|
||||
| Drug Name |
Brutieridin
|
||||
| Synonyms |
Brutieridin; Melitidin; Bergamot juice flavonoids (hypercholesterolemia), Biopharm technologies; Brutieridin/melitidin (hypercholesterolemia), Biopharm technologies
|
||||
| Indication | Hypercholesterolemia [ICD10:E78] | Investigative | [1] | ||
| Company |
Biopharm Technology Corp
|
||||
| Structure |
|
Download2D MOL |
|||
| Canonical SMILES |
[C@@H]1([C@@H](O[C@@H]([C@H]([C@@H]1O)O)COC(=O)CC(CC(=O<br />)O)(O)C)Oc1cc2c(C(=O)C[C@H](O2)c2cc(c(cc2)OC)O)c(c1)O)O<br />[C@@H]1[C@H]([C@H]([C@@H]([C@H](O1)C)O)O)O
|
||||
| Target and Pathway | |||||
| Target(s) | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Target Info | Inhibitor | [1] | |
| BioCyc Pathway | Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) | ||||
| Superpathway of cholesterol biosynthesis | |||||
| Mevalonate pathway | |||||
| KEGG Pathway | Terpenoid backbone biosynthesis | ||||
| Metabolic pathways | |||||
| Biosynthesis of antibiotics | |||||
| AMPK signaling pathway | |||||
| Bile secretion | |||||
| NetPath Pathway | IL5 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | |||||
| TSH Signaling Pathway | |||||
| PANTHER Pathway | Cholesterol biosynthesis | ||||
| PathWhiz Pathway | Steroid Biosynthesis | ||||
| WikiPathways | Statin Pathway | ||||
| Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | |||||
| Activation of Gene Expression by SREBP (SREBF) | |||||
| SREBF and miR33 in cholesterol and lipid homeostasis | |||||
| Integrated Breast Cancer Pathway | |||||
| SREBP signalling | |||||
| Cholesterol Biosynthesis | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 639). | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.