| Drug General Information |
| Drug ID |
D0TU7B
|
| Former ID |
DIB018035
|
| Drug Name |
PQR309
|
| Drug Type |
Small molecular drug
|
| Indication |
Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89]
|
Phase 1 |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C17H20F3N7O2
|
| InChIKey |
ADGGYDAFIHSYFI-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
|
| Target and Pathway |
| Target(s) |
Serine/threonine-protein kinase mTOR |
Target Info |
Inhibitor |
[2]
|
|---|
| Phosphoinositide 3 kinase |
Target Info |
Inhibitor |
[3]
|
| PI3K beta |
Target Info |
Inhibitor |
[4]
|
|
BioCyc Pathway
|
Superpathway of inositol phosphate compounds
|
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3-phosphoinositide biosynthesis
|
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KEGG Pathway
|
ErbB signaling pathway
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HIF-1 signaling pathway
|
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mTOR signaling pathway
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PI3K-Akt signaling pathway
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AMPK signaling pathway
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Insulin signaling pathway
|
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Thyroid hormone signaling pathway
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Adipocytokine signaling pathway
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|
Type II diabetes mellitus
|
|
Pathways in cancer
|
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Proteoglycans in cancer
|
|
MicroRNAs in cancer
|
|
Glioma
|
|
Prostate cancer
|
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Acute myeloid leukemia
|
|
Central carbon metabolism in cancer
|
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Choline metabolism in cancerhsa00562:Inositol phosphate metabolism
|
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Ras signaling pathway
|
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Rap1 signaling pathway
|
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cGMP-PKG signaling pathway
|
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cAMP signaling pathway
|
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Chemokine signaling pathway
|
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FoxO signaling pathway
|
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Phosphatidylinositol signaling system
|
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Sphingolipid signaling pathway
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Apoptosis
|
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Adrenergic signaling in cardiomyocytes
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|
VEGF signaling pathway
|
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Osteoclast differentiation
|
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Focal adhesion
|
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Signaling pathways regulating pluripotency of stem cells
|
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Platelet activation
|
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Toll-like receptor signaling pathway
|
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Jak-STAT signaling pathway
|
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Natural killer cell mediated cytotoxicity
|
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T cell receptor signaling pathway
|
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B cell receptor signaling pathway
|
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Fc epsilon RI signaling pathway
|
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Fc gamma R-mediated phagocytosis
|
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TNF signaling pathway
|
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Leukocyte transendothelial migration
|
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Neurotrophin signaling pathway
|
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Cholinergic synapse
|
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Inflammatory mediator regulation of TRP channels
|
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Regulation of actin cytoskeleton
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Progesterone-mediated oocyte maturation
|
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Estrogen signaling pathway
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Prolactin signaling pathway
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Oxytocin signaling pathway
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Regulation of lipolysis in adipocytes
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Non-alcoholic fatty liver disease (NAFLD)
|
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Aldosterone-regulated sodium reabsorption
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Carbohydrate digestion and absorption
|
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Bacterial invasion of epithelial cells
|
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Chagas disease (American trypanosomiasis)
|
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Toxoplasmosis
|
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Amoebiasis
|
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Hepatitis C
|
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Hepatitis B
|
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Measles
|
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Influenza A
|
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HTLV-I infection
|
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Epstein-Barr virus infection
|
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Viral carcinogenesis
|
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Colorectal cancer
|
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Renal cell carcinoma
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Pancreatic cancer
|
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Endometrial cancer
|
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Melanoma
|
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Chronic myeloid leukemia
|
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Small cell lung cancer
|
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Non-small cell lung cancer
|
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Choline metabolism in cancer
|
|
PANTHER Pathway
|
Hypoxia response via HIF activation
|
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Interleukin signaling pathwayP00005:Angiogenesis
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Apoptosis signaling pathway
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Axon guidance mediated by netrin
|
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B cell activation
|
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EGF receptor signaling pathway
|
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Endothelin signaling pathway
|
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FGF signaling pathway
|
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Inflammation mediated by chemokine and cytokine signaling pathway
|
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Insulin/IGF pathway-protein kinase B signaling cascade
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Integrin signalling pathway
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Interleukin signaling pathway
|
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PDGF signaling pathway
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PI3 kinase pathway
|
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T cell activation
|
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VEGF signaling pathway
|
|
p53 pathway
|
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Ras Pathway
|
|
p53 pathway feedback loops 2
|
|
CCKR signaling map ST
|
|
Pathway Interaction Database
|
IL4-mediated signaling events
|
|
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
|
|
IL12-mediated signaling events
|
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CDC42 signaling events
|
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LKB1 signaling events
|
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Regulation of Telomerase
|
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mTOR signaling pathway
|
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CXCR4-mediated signaling events
|
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EGFR-dependent Endothelin signaling events
|
|
IL2 signaling events mediated by PI3K
|
|
IFN-gamma pathway
|
|
ErbB1 downstream signaling
|
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ErbB2/ErbB3 signaling events
|
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CXCR3-mediated signaling events
|
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Class I PI3K signaling events mediated by Akterbb4_pathway:ErbB4 signaling events
|
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LPA receptor mediated events
|
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TRAIL signaling pathway
|
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Signaling events mediated by TCPTP
|
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FAS (CD95) signaling pathway
|
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EGF receptor (ErbB1) signaling pathway
|
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Class I PI3K signaling events
|
|
PDGFR-beta signaling pathway
|
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Nephrin/Neph1 signaling in the kidney podocyte
|
|
Internalization of ErbB1
|
|
PathWhiz Pathway
|
Leucine Stimulation on Insulin SignalingPW000143:Inositol Metabolism
|
|
Phosphatidylinositol Phosphate Metabolism
|
|
Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
|
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Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
|
|
Fc Epsilon Receptor I Signaling in Mast Cells
|
|
Reactome
|
PIP3 activates AKT signaling
|
|
Macroautophagy
|
|
mTORC1-mediated signalling
|
|
HSF1-dependent transactivation
|
|
CD28 dependent PI3K/Akt signaling
|
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VEGFR2 mediated vascular permeability
|
|
TP53 Regulates Metabolic Genes
|
|
Constitutive Signaling by AKT1 E17K in CancerR-HSA-109704:PI3K Cascade
|
|
GPVI-mediated activation cascade
|
|
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
|
|
PI3K events in ERBB4 signaling
|
|
GAB1 signalosome
|
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PI3K events in ERBB2 signaling
|
|
PI3K/AKT activation
|
|
Role of phospholipids in phagocytosis
|
|
Tie2 Signaling
|
|
Constitutive Signaling by Aberrant PI3K in Cancer
|
|
DAP12 signaling
|
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Role of LAT2/NTAL/LAB on calcium mobilization
|
|
Nephrin interactions
|
|
Costimulation by the CD28 family
|
|
G beta:gamma signalling through PI3Kgamma
|
|
G alpha (q) signalling events
|
|
G alpha (12/13) signalling events
|
|
VEGFA-VEGFR2 Pathway
|
|
Interleukin-3, 5 and GM-CSF signaling
|
|
Constitutive Signaling by EGFRvIII
|
|
PI-3K cascade:FGFR1
|
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PI-3K cascade:FGFR2
|
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PI-3K cascade:FGFR3
|
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PI-3K cascade:FGFR4
|
|
Interleukin receptor SHC signaling
|
|
Regulation of signaling by CBLR-HSA-109704:PI3K Cascade
|
|
Regulation of signaling by CBL
|
|
WikiPathways
|
ErbB Signaling Pathway
|
|
Senescence and Autophagy in Cancer
|
|
Interferon type I signaling pathways
|
|
Insulin Signaling
|
|
EGF/EGFR Signaling Pathway
|
|
Wnt Signaling Pathway Netpath
|
|
Extracellular vesicle-mediated signaling in recipient cells
|
|
Cardiac Hypertrophic Response
|
|
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
|
|
PIP3 activates AKT signaling
|
|
Polycystic Kidney Disease Pathway
|
|
Alpha 6 Beta 4 signaling pathway
|
|
BDNF signaling pathway
|
|
Oncostatin M Signaling Pathway
|
|
Prostate Cancer
|
|
TSLP Signaling Pathway
|
|
FSH signaling pathway
|
|
Leptin signaling pathway
|
|
TSH signaling pathway
|
|
RANKL/RANK Signaling Pathway
|
|
SREBF and miR33 in cholesterol and lipid homeostasis
|
|
Integrated Breast Cancer Pathway
|
|
SREBP signalling
|
|
Signaling by Insulin receptor
|
|
Costimulation by the CD28 family
|
|
Type II diabetes mellitus
|
|
MicroRNAs in cardiomyocyte hypertrophy
|
|
TOR Signaling
|
|
AMPK SignalingWP75:Toll-like receptor signaling pathway
|
|
Serotonin HTR1 Group and FOS Pathway
|
|
DNA Damage Response (only ATM dependent)
|
|
G13 Signaling Pathway
|
|
Regulation of Actin Cytoskeleton
|
|
IL-4 Signaling Pathway
|
|
Copper homeostasis
|
|
Signaling of Hepatocyte Growth Factor Receptor
|
|
Transcriptional activation by NRF2
|
|
IL1 and megakaryotyces in obesity
|
|
Signaling by ERBB4
|
|
Signaling by ERBB2
|
|
Fc epsilon receptor (FCERI) signaling
|
|
PI Metabolism
|
|
Interleukin-2 signaling
|
|
Fcgamma receptor (FCGR) dependent phagocytosis
|
|
Signaling by SCF-KIT
|
|
DAP12 interactions
|
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
|
Integrated Pancreatic Cancer Pathway
|
|
Signaling Pathways in Glioblastoma
|
|
Regulation of Microtubule Cytoskeleton
|
|
TCR signaling
|
|
Signaling by PDGF
|
|
Signaling by FGFR
|
|
Signaling by EGFR
|
|
NGF signalling via TRKA from the plasma membrane
|
|
Nephrin interactions
|
|
Interleukin-3, 5 and GM-CSF signaling
|
|
GPVI-mediated activation cascade
|
|
GPCR downstream signaling
|
|
Cell surface interactions at the vascular wall
|
|
Angiogenesis
|
|
Regulation of toll-like receptor signaling pathway
|
|
AMPK Signaling
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8383). |
|---|
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2109). |
|---|
| REF 3 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2155). |
|---|
| REF 4 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2154). |
|---|
