Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0V4KL
|
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| Former ID |
DIB014025
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| Drug Name |
VAR-10200
|
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| Synonyms |
HLA-20
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| Drug Type |
Small molecular drug
|
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| Indication | Neurodegenerative disease [ICD9: 330-337; ICD10:G30-G32] | Investigative | [1] | ||
| Company |
Varinel Inc
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C17H19N3O
|
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| Canonical SMILES |
c1cc(c2c(c1)c(ccn2)CN1CCN(CC1)CC#C)O
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Amine oxidase [flavin-containing] B | Target Info | Modulator | [1] | |
| BioCyc Pathway | Superpathway of tryptophan utilization | ||||
| Tryptophan degradation via tryptamine | |||||
| Dopamine degradation | |||||
| Putrescine degradation III | |||||
| Noradrenaline and adrenaline degradation | |||||
| KEGG Pathway | Glycine, serine and threonine metabolism | ||||
| Arginine and proline metabolism | |||||
| Histidine metabolism | |||||
| Tyrosine metabolism | |||||
| Phenylalanine metabolism | |||||
| Tryptophan metabolism | |||||
| Drug metabolism - cytochrome P450 | |||||
| Metabolic pathways | |||||
| Serotonergic synapse | |||||
| Dopaminergic synapse | |||||
| Cocaine addiction | |||||
| Amphetamine addiction | |||||
| Alcoholism | |||||
| PANTHER Pathway | Adrenaline and noradrenaline biosynthesis | ||||
| 5-Hydroxytryptamine degredation | |||||
| Dopamine receptor mediated signaling pathway | |||||
| Pathway Interaction Database | Alpha-synuclein signaling | ||||
| WikiPathways | Tryptophan metabolism | ||||
| Dopamine metabolism | |||||
| Phase 1 - Functionalization of compounds | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2490). | ||||
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