Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0V7GB
|
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| Former ID |
DIB015881
|
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| Drug Name |
MMP-13 inhibitors
|
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| Synonyms |
MMP-13 inhibitors (osteoarthritis); MMP-13 inhibitors (osteoarthritis), AstraZeneca; Metalloprotease-13 (osteoarthritis), AstraZeneca
|
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| Indication | Osteoarthritis [ICD9: 715; ICD10:M15-M19, M47] | Investigative | [1] | ||
| Company |
AstraZeneca plc
|
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| Structure |
|
Download2D MOL |
|||
| Canonical SMILES |
[C@]1([C@H]2CCN(C1)CC2)(C#Cc1ccc(Oc2ccc(C(=O)NCc3ncncc3<br />)cc2)cc1)O
|
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| Target and Pathway | |||||
| Target(s) | Collagenase 3 | Target Info | Inhibitor | [2], [3] | |
| NetPath Pathway | IL1 Signaling Pathway | ||||
| PANTHER Pathway | Alzheimer disease-presenilin pathway | ||||
| Plasminogen activating cascade | |||||
| Pathway Interaction Database | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling | ||||
| Reactome | Collagen degradation | ||||
| Degradation of the extracellular matrix | |||||
| Activation of Matrix Metalloproteinases | |||||
| Assembly of collagen fibrils and other multimeric structures | |||||
| WikiPathways | Endochondral Ossification | ||||
| Activation of Matrix Metalloproteinases | |||||
| Oncostatin M Signaling Pathway | |||||
| AGE/RAGE pathway | |||||
| Matrix Metalloproteinases | |||||
| References | |||||
| REF 1 | Hydantoin based inhibitors of MMP13--discovery of AZD6605. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4705-12 | ||||
| REF 2 | Effects of selective matrix metalloproteinase inhibitor (PG-116800) to prevent ventricular remodeling after myocardial infarction: results of the PREMIER (Prevention of Myocardial Infarction Early Remodeling) trial. J Am Coll Cardiol. 2006 Jul 4;48(1):15-20. Epub 2006 Jun 21. | ||||
| REF 3 | Selective matrix metalloproteinase inhibition attenuates progression of left ventricular dysfunction and remodeling in dogs with chronic heart failure. Am J Physiol Heart Circ Physiol. 2006 Jun;290(6):H2522-7. Epub 2006 Jan 20. | ||||
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