Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0W0SL
|
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| Former ID |
DNCL002711
|
||||
| Drug Name |
LY2940680
|
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| Drug Type |
Small molecular drug
|
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| Indication | Cancer [ICD9: 140-229; ICD10:C00-C96] | Phase 1/2 | [1] | ||
| Company |
Lilly
|
||||
| Structure |
|
Download2D MOL |
|||
| Formula |
C26H24F4N6O
|
||||
| Canonical SMILES |
CN1C(=CC=N1)C2=NN=C(C3=CC=CC=C32)N4CCC(CC4)N(C)C(=O)C5=<br />C(C=C(C=C5)F)C(F)(F)F
|
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| InChI |
1S/C26H24F4N6O/c1-34(25(37)20-8-7-16(27)15-21(20)26(28,29)30)17-10-13-36(14-11-17)24-19-6-4-3-5-18(19)23(32-33-24)22-9-12-31-35(22)2/h3-9,12,15,17H,10-11,13-14H2,1-2H3
|
||||
| InChIKey |
SZBGQDXLNMELTB-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
104176324, 121139787, 136340242, 136348732, 136367587, 137276014, 141374772, 144116170, 152258481, 160647316, 162011773, 162038053, 162163233, 162202792, 163831677, 174494770, 174527001, 185990483, 189622858, 196408582, 198968197, 223391308, 223705123, 224461079, 228265210, 245597767, 251910779, 252110150, 252160815
|
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| Target and Pathway | |||||
| Target(s) | smoothened receptor | Target Info | Modulator | [2] | |
| KEGG Pathway | Hedgehog signaling pathway | ||||
| Pathways in cancer | |||||
| Proteoglycans in cancer | |||||
| Basal cell carcinoma | |||||
| PANTHER Pathway | Hedgehog signaling pathway | ||||
| Pathway Interaction Database | Signaling events mediated by the Hedgehog family | ||||
| Hedgehog signaling events mediated by Gli proteins | |||||
| Reactome | Class B/2 (Secretin family receptors) | ||||
| Hedgehog 'off' state | |||||
| Activation of SMO | |||||
| WikiPathways | Hedgehog Signaling Pathway | ||||
| Hair Follicle Development: Organogenesis (Part 2 of 3) | |||||
| Hair Follicle Development: Induction (Part 1 of 3) | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| GPCR ligand binding | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | ClinicalTrials.gov (NCT01722292) A Study of LY2940680 in Small Cell Lung Cancer. U.S. National Institutes of Health. | ||||
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | ||||
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