| Drug General Information |
| Drug ID |
D0Z3CZ
|
| Former ID |
DNC014869
|
| Drug Name |
5-(2-methylpiperazin-1-ylsulfonyl)isoquinoline
|
| Drug Type |
Small molecular drug
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| Indication |
Discovery agent
|
Investigative |
[1]
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| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C14H17N3O2S
|
| Canonical SMILES |
CC1CNCCN1S(=O)(=O)C2=CC=CC3=C2C=CN=C3
|
| InChI |
1S/C14H17N3O2S/c1-11-9-16-7-8-17(11)20(18,19)14-4-2-3-12-10-15-6-5-13(12)14/h2-6,10-11,16H,7-9H2,1H3
|
| InChIKey |
BDVFVCGFMNCYPV-UHFFFAOYSA-N
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| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
CAMP-dependent protein kinase type I-alpha regulatory chain |
Target Info |
Inhibitor |
[1]
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KEGG Pathway
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Apoptosis
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Insulin signaling pathway
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NetPath Pathway
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FSH Signaling Pathway
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PANTHER Pathway
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Endothelin signaling pathway
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Hedgehog signaling pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Metabotropic glutamate receptor group III pathway
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Metabotropic glutamate receptor group II pathway
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Metabotropic glutamate receptor group I pathway
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Muscarinic acetylcholine receptor 2 and 4 signaling pathway
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Transcription regulation by bZIP transcription factor
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GABA-B receptor II signaling
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Pathway Interaction Database
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Alpha4 beta1 integrin signaling events
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PathWhiz Pathway
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Muscle/Heart Contraction
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Reactome
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PKA activation
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PKA activation in glucagon signalling
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DARPP-32 events
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Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
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Vasopressin regulates renal water homeostasis via Aquaporins
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Hedgehog 'off' state
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Factors involved in megakaryocyte development and platelet production
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WikiPathways
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SIDS Susceptibility Pathways
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Calcium Regulation in the Cardiac Cell
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G Protein Signaling Pathways
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Myometrial Relaxation and Contraction Pathways
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Mesodermal Commitment Pathway
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DAG and IP3 signaling
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Regulation of Water Balance by Renal Aquaporins
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miRs in Muscle Cell Differentiation
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Opioid Signalling
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Integration of energy metabolism
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Factors involved in megakaryocyte development and platelet production
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| References |
| REF 1 | J Biol Chem. 1996 Oct 18;271(42):26157-64.Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity. |
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