Resistance mutation info of target

Target General Information
Target ID T00820
Target Name ATP-sensitive inward rectifier potassium channel 11 (KCNJ11) Target Info
Gene Name KCNJ11
Species Homo sapiens
Uniprot ID KCJ11_HUMAN
Sequence MLSRKGIIPEEYVLTRLAEDPAEPRYRARQRRARFVSKKGNCNVAHKNIREQGRFLQDVF
TTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSEGTAEPCVTSIHSFSSA
FLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAET
LIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPM
ENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQA
RTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTARQLDEDHSLLEALT
LASARGPLRKRSVPMAKAKPKFSISPDSLS [Homo sapiens]
Drug Resistance Mutation and Corresponding Drugs
Mutation Info Missense: R201C
Drugs
Drug Name Sulfonylurea Drug Info [1559295]
Targeted Disease Permanent neonatal diabetes mellitus
Reference
Ref 1559295Permanent neonatal diabetes mellitus due to KCNJ11 mutation in a Portuguese family: transition from insulin to oral sulfonylureas.

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