Resistance mutation info of target

Target General Information
Target ID T56915
Target Name HIV Protease Target Info
Species Human immunodeficiency virus type 1 (HIV-1)
Uniprot ID POL_HV1B1(501-599)
Sequence PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF [Human immunodeficie
ncy virus type 1 (HIV-1)]
Drug Resistance Mutation and Corresponding Drugs
Ref 545337Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002887)
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 521751ClinicalTrials.gov (NCT00246610) Safety Of VIRACEPT 625mg Administered To HIV-Infected Women During Pregnancy. U.S. National Institutes of Health.
Mutation Info Missense: D30N
Drugs
Drug Name Nelfinavir Drug Info [555734]
Targeted Disease HIV infection
Level of Resistance Confer high-level resistance to NFV
Mutation Info Missense: F53L
Drugs
Drug Name Nelfinavir Drug Info [555510], [555637], [555764]
Targeted Disease HIV infection
Level of Resistance Reduce susceptibility to NFV
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: G48A
Drugs
Drug Name Nelfinavir Drug Info [556228], [556244]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Mutation Info Missense: G48L
Drugs
Drug Name Nelfinavir Drug Info [556228], [556244]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Mutation Info Missense: G48M
Drugs
Drug Name Nelfinavir Drug Info [555517], [555635], [555637]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234]
Targeted Disease HIV infection
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Mutation Info Missense: G48Q
Drugs
Drug Name Nelfinavir Drug Info [556228], [556244]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Mutation Info Missense: G48S
Drugs
Drug Name Nelfinavir Drug Info [556228], [556244]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Mutation Info Missense: G48T
Drugs
Drug Name Nelfinavir Drug Info [556228], [556244]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Mutation Info Missense: G48V
Drugs
Drug Name Nelfinavir Drug Info [555764]
Targeted Disease HIV infection
Level of Resistance Confer intermediate-level resistance to NFV
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234]
Targeted Disease HIV infection
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Mutation Info Missense: G73A
Drugs
Drug Name Nelfinavir Drug Info [556228], [556244]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: G73C
Drugs
Drug Name Nelfinavir Drug Info [556228], [556244]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: G73S
Drugs
Drug Name Nelfinavir Drug Info [556228], [556244]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: G73T
Drugs
Drug Name Nelfinavir Drug Info [556228], [556244]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: I47A
Drugs
Drug Name Nelfinavir Drug Info [556228], [556244]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Darunavir + Ritonavir Drug Info [556226], [556228]
Targeted Disease HIV infection
Mutation Info Missense: I47V
Drugs
Drug Name Nelfinavir Drug Info [556228], [556244]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Darunavir + Ritonavir Drug Info [556226], [556228]
Targeted Disease HIV infection
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Mutation Info Missense: I50L
Drugs
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Mutation Info Missense: I50V
Drugs
Drug Name Nelfinavir Drug Info [556228], [556244]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Darunavir + Ritonavir Drug Info [556226], [556228]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: I54A
Drugs
Drug Name Nelfinavir Drug Info [556228], [556244], [556245]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: I54L
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234], [556235]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Darunavir + Ritonavir Drug Info [556226], [556228]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: I54M
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234], [556235]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Darunavir + Ritonavir Drug Info [556226], [556228]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: I54S
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556235]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: I54T
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234], [556235]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: I54V
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234], [556235]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: I84A
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Darunavir + Ritonavir Drug Info [556226], [556228]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Mutation Info Missense: I84C
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Darunavir + Ritonavir Drug Info [556226], [556228]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Mutation Info Missense: I84V
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Darunavir + Ritonavir Drug Info [556226], [556228]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Mutation Info Missense: K20T
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: K65R
Drugs
Drug Name Nelfinavir Drug Info [556112]
Targeted Disease HIV infection
Mutation Prevalence 7 out of 37 samples
Mutation Info Missense: L10F
Drugs
Drug Name Nelfinavir Drug Info [555646], [555673], [555679]
Targeted Disease HIV infection
Level of Resistance Reduce susceptibility to NFV in vitro
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: L23I
Drugs
Drug Name Nelfinavir Drug Info [555551]
Targeted Disease HIV infection
Level of Resistance Confer low/intermediate-level resistance to NFV
Mutation Info Missense: L24F
Drugs
Drug Name Nelfinavir Drug Info [555726], [555764]
Targeted Disease HIV infection
Level of Resistance Reduce susceptibility to NFV
Mutation Info Missense: L24I
Drugs
Drug Name Nelfinavir Drug Info [556195]
Targeted Disease HIV infection
Level of Resistance Reduce susceptibility to NFV
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: L33F
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234]
Targeted Disease HIV infection
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Drug Name Darunavir + Ritonavir Drug Info [556226], [556228]
Targeted Disease HIV infection
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Mutation Info Missense: L76V
Drugs
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Darunavir + Ritonavir Drug Info [556226], [556228]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: L89V
Drugs
Drug Name Nelfinavir Drug Info [555510], [555648], [555678]
Targeted Disease HIV infection
Level of Resistance Reduce susceptibility to NFV
Mutation Info Missense: L90M
Drugs
Drug Name Nelfinavir Drug Info [556184]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234], [556235]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: L90M
Drugs
Drug Name Nelfinavir Drug Info [555965]
Targeted Disease HIV infection
Mutation Prevalence 1 out of 31 samples
Mutation Info Missense: M36I + H69K + L89M
Drugs
Drug Name Tipranavir Drug Info [555812]
Targeted Disease HIV infection
Mutation Info Missense: M41L
Drugs
Drug Name Tenofovir + Emtricitabine + Efavirenz Drug Info [556145]
Targeted Disease HIV infection
Mutation Info Missense: M46*
Drugs
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Mutation Info Missense: M46I
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234]
Targeted Disease HIV infection
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Mutation Info Missense: M46L
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234]
Targeted Disease HIV infection
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Mutation Info Missense: M46V
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: N83D
Drugs
Drug Name Nelfinavir Drug Info [555606], [555764], [555778]
Targeted Disease HIV infection
Level of Resistance Reduce susceptibility to NFV
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: N88D
Drugs
Drug Name Nelfinavir Drug Info [556221]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Mutation Info Missense: N88G
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: N88S
Drugs
Drug Name Nelfinavir Drug Info [556221]
Targeted Disease HIV infection
Level of Resistance Reduce susceptibility to NFV
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Mutation Info Missense: N88T
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: Q58E
Drugs
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: T74P
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: T74S
Drugs
Drug Name Ritonavir Drug Info [555724]
Targeted Disease HIV infection
Mutation Info Missense: V32I
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234], [556235]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Darunavir + Ritonavir Drug Info [556226], [556228]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: V82A
Drugs
Drug Name Nelfinavir Drug Info [555510]
Targeted Disease HIV infection
Level of Resistance Confer reduce susceptibility to NFV
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239], [556240]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: V82C
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556235]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: V82F
Drugs
Drug Name Nelfinavir Drug Info [555764]
Targeted Disease HIV infection
Level of Resistance Reduce susceptibility to NFV
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Darunavir + Ritonavir Drug Info [556226], [556228]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: V82L
Drugs
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: V82M
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556235]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: V82S
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239], [556240]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Mutation Info Missense: V82T
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232], [556233]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239], [556240]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Reference
Ref 555510Human immunodeficiency virus reverse transcriptase and protease sequence database. Nucleic Acids Res. 2003 Jan 1;31(1):298-303.
Ref 555517Improving lopinavir genotype algorithm through phenotype correlations: novel mutation patterns and amprenavir cross-resistance. AIDS. 2003 May 2;17(7):955-61.
Ref 556226Current patterns in the epidemiology of primary HIV drug resistance in North America and Europe. Antivir Ther. 2004 Oct;9(5):695-702.
Ref 555551Association of a novel human immunodeficiency virus type 1 protease substrate cleft mutation, L23I, with protease inhibitor therapy and in vitro drug resistance. Antimicrob Agents Chemother. 2004 Dec;48(12):4864-8.
Ref 555606Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol. 2006 Nov;80(21):10794-801. Epub 2006 Aug 23.
Ref 555635HIV-1 subtype B protease and reverse transcriptase amino acid covariation. PLoS Comput Biol. 2007 May;3(5):e87.
Ref 555637Prediction of HIV-1 drug susceptibility phenotype from the viral genotype using linear regression modeling. J Virol Methods. 2007 Oct;145(1):47-55. Epub 2007 Jun 15.
Ref 555646Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137). J Virol. 2008 Jan;82(2):764-74. Epub 2007 Oct 31.
Ref 555648Factors associated with the selection of mutations conferring resistance to protease inhibitors (PIs) in PI-experienced patients displaying treatment failure on darunavir. Antimicrob Agents Chemother. 2008 Feb;52(2):491-6. Epub 2007 Nov 26.
Ref 555673Selection of diverse and clinically relevant integrase inhibitor-resistant human immunodeficiency virus type 1 mutants. Antiviral Res. 2008 Nov;80(2):213-22. doi: 10.1016/j.antiviral.2008.06.012. Epub 2008 Jul 14.
Ref 555678Pattern and impact of emerging resistance mutations in treatment experienced patients failing darunavir-containing regimen. AIDS. 2008 Sep 12;22(14):1809-13. doi: 10.1097/QAD.0b013e328307f24a.
Ref 555679Resistance mutations in human immunodeficiency virus type 1 integrase selected with elvitegravir confer reduced susceptibility to a wide range of integrase inhibitors. J Virol. 2008 Nov;82(21):10366-74. doi: 10.1128/JVI.00470-08. Epub 2008 Aug 20.
Ref 555724Mutation T74S in HIV-1 subtype B and C proteases resensitizes them to ritonavir and indinavir and confers fitness advantage. J Antimicrob Chemother. 2009 Nov;64(5):938-44. doi: 10.1093/jac/dkp315. Epub 2009 Aug 26.
Ref 555726Nonpolymorphic human immunodeficiency virus type 1 protease and reverse transcriptase treatment-selected mutations. Antimicrob Agents Chemother. 2009 Nov;53(11):4869-78. doi: 10.1128/AAC.00592-09. Epub 2009 Aug 31.
Ref 555734Postpartum antiretroviral drug resistance in HIV-1-infected women receiving pregnancy-limited antiretroviral therapy. AIDS. 2010 Jan 2;24(1):45-53. doi: 10.1097/QAD.0b013e32832e5303.
Ref 555764HIV-1 protease mutations and protease inhibitor cross-resistance. Antimicrob Agents Chemother. 2010 Oct;54(10):4253-61. doi: 10.1128/AAC.00574-10. Epub 2010 Jul 26.
Ref 555778Improving the prediction of virological response to tipranavir: the development and validation of a tipranavir-weighted mutation score. Antivir Ther. 2010;15(7):1011-9. doi: 10.3851/IMP1670.
Ref 555812Prediction of drug-resistance in HIV-1 subtype C based on protease sequences from ART naive and first-line treatment failures in North India using genotypic and docking analysis. Antiviral Res. 2011 Nov;92(2):213-8. doi: 10.1016/j.antiviral.2011.08.005. Epub 2011 Aug 22.
Ref 556228The HIVdb system for HIV-1 genotypic resistance interpretation. Intervirology. 2012;55(2):98-101. doi: 10.1159/000331998. Epub 2012 Jan 24.
Ref 555965HIV-1 drug-resistance surveillance among treatment-experienced and -nae patients after the implementation of antiretroviral therapy in Ghana. PLoS One. 2013 Aug 19;8(8):e71972. doi: 10.1371/journal.pone.0071972. eCollection 2013.
Ref 556232Personalized HIV therapy to control drug resistance. Drug Discov Today Technol. 2014 Mar;11:57-64. doi: 10.1016/j.ddtec.2014.02.004.
Ref 556233The emerging profile of cross-resistance among the nonnucleoside HIV-1 reverse transcriptase inhibitors. Viruses. 2014 Jul 31;6(8):2960-73. doi: 10.3390/v6082960.
Ref 556234Drug resistance in non-B subtype HIV-1: impact of HIV-1 reverse transcriptase inhibitors. Viruses. 2014 Sep 24;6(9):3535-62. doi: 10.3390/v6093535.
Ref 556235Current perspectives on HIV-1 antiretroviral drug resistance. Viruses. 2014 Oct 24;6(10):4095-139. doi: 10.3390/v6104095.
Ref 556239Resistance to direct-acting antiviral agents: clinical utility and significance. Curr Opin HIV AIDS. 2015 Sep;10(5):381-9. doi: 10.1097/COH.0000000000000177.
Ref 556240Resistance to reverse transcriptase inhibitors used in the treatment and prevention of HIV-1 infection. Future Microbiol. 2015;10(11):1773-82. doi: 10.2217/fmb.15.106. Epub 2015 Oct 30.
Ref 556112Prevalence and dynamics of the K65R drug resistance mutation in HIV-1-infected infants exposed to maternal therapy with lamivudine, zidovudine and either nevirapine or nelfinavir in breast milk. J Antimicrob Chemother. 2016 Jun;71(6):1619-26. doi: 10.1093/jac/dkw039. Epub 2016 Mar 6.
Ref 556145HIV Drug Resistance in Antiretroviral Treatment-Nae Individuals in the Largest Public Hospital in Nicaragua, 2011-2015. PLoS One. 2016 Oct 13;11(10):e0164156. doi: 10.1371/journal.pone.0164156. eCollection 2016.
Ref 556244Tackling the problem of HIV drug resistance. Postepy Biochem. 2016;62(3):273-279.
Ref 556245How to win the HIV-1 drug resistance hurdle race: running faster or jumping higher? Biochem J. 2017 Apr 26;474(10):1559-1577. doi: 10.1042/BCJ20160772.
Ref 556247Clinical correlates and molecular basis of HIV drug resistance. J Acquir Immune Defic Syndr. 1993;6 Suppl 1:S36-46.
Ref 556184The effect of high-dose saquinavir on viral load and CD4+ T-cell counts in HIV-infected patients. Ann Intern Med. 1996 Jun 15;124(12):1039-50.
Ref 556195Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor. J Virol. 1996 Dec;70(12):8270-6.
Ref 556221Genotypic and phenotypic characterization of human immunodeficiency virus type 1 variants isolated from patients treated with the protease inhibitor nelfinavir. Antimicrob Agents Chemother. 1998 Oct;42(10):2637-44.

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