Target General Information |
Target ID |
T88240 |
Target Name |
Bacterial Hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase (DHPS) |
Target Info
|
Gene Name |
folP |
Species |
Escherichia coli |
Uniprot ID |
DHPS_ECOLI |
Sequence |
MKLFAQGTSLDLSHPHVMGILNVTPDSFSDGGTHNSLIDAVKHANLMINAGATIIDVGGE STRPGAAEVSVEEELQRVIPVVEAIAQRFEVWISVDTSKPEVIRESAKVGAHIINDIRSL SEPGALEAAAETGLPVCLMHMQGNPKTMQEAPKYDDVFAEVNRYFIEQIARCEQAGIAKE KLLLDPGFGFGKNLSHNYSLLARLAEFHHFNLPLLVGMSRKSMIGQLLNVGPSERLSGSL ACAVIAAMQGAHIIRVHDVKETVEAMRVVEATLSAKENKRYE [Escherichia coli ] |
Drug Resistance Mutation and Corresponding Drugs |
Mutation Info |
Missense: A587V |
Drugs |
Drug Name |
Sulfadiazine |
Drug Info |
[1]
|
Targeted Disease |
Toxoplasmosis |
|
Mutation Info |
Missense: F25I |
Drugs |
Drug Name |
Sulfonamide |
Drug Info |
[2]
|
Targeted Disease |
Bacterial infection |
|
Mutation Info |
Missense: K540E |
Drugs |
Drug Name |
Sulfamethoxazole |
Drug Info |
[3]
|
Targeted Disease |
Plasmodium Falciparum Malaria |
|
Mutation Info |
Missense: K540N |
Drugs |
Drug Name |
Sulfamethoxazole |
Drug Info |
[3]
|
Targeted Disease |
Plasmodium Falciparum Malaria |
|
Mutation Info |
Missense: P55A |
Drugs |
Drug Name |
Dapsone |
Drug Info |
[4]
|
Targeted Disease |
Hansen disease |
|
Mutation Info |
Missense: P55H |
Drugs |
Drug Name |
Dapsone |
Drug Info |
[4]
|
Targeted Disease |
Hansen disease |
|
Mutation Info |
Missense: P55L |
Drugs |
Drug Name |
Dapsone |
Drug Info |
[4]
|
Targeted Disease |
Hansen disease |
|
Mutation Info |
Missense: P55R |
Drugs |
Drug Name |
Dapsone |
Drug Info |
[4]
|
Targeted Disease |
Hansen disease |
|
Mutation Info |
Missense: P55S |
Drugs |
Drug Name |
Dapsone |
Drug Info |
[4]
|
Targeted Disease |
Hansen disease |
|
Mutation Info |
Missense: P55T |
Drugs |
Drug Name |
Dapsone |
Drug Info |
[4]
|
Targeted Disease |
Hansen disease |
|
Mutation Info |
Missense: P64A |
Drugs |
Drug Name |
Sulfonamide |
Drug Info |
[4]
|
Targeted Disease |
Bacterial infection |
|
Mutation Info |
Missense: P64H |
Drugs |
Drug Name |
Sulfonamide |
Drug Info |
[4]
|
Targeted Disease |
Bacterial infection |
|
Mutation Info |
Missense: P64L |
Drugs |
Drug Name |
Sulfonamide |
Drug Info |
[4]
|
Targeted Disease |
Bacterial infection |
|
Mutation Info |
Missense: P64R |
Drugs |
Drug Name |
Sulfonamide |
Drug Info |
[4]
|
Targeted Disease |
Bacterial infection |
|
Mutation Info |
Missense: P64S |
Drugs |
Drug Name |
Sulfonamide |
Drug Info |
[4]
|
Targeted Disease |
Bacterial infection |
|
Mutation Info |
Missense: T53A |
Drugs |
Drug Name |
Dapsone |
Drug Info |
[4]
|
Targeted Disease |
Hansen disease |
|
Mutation Info |
Missense: T53I |
Drugs |
Drug Name |
Dapsone |
Drug Info |
[4]
|
Targeted Disease |
Hansen disease |
|
Mutation Info |
Missense: T53N |
Drugs |
Drug Name |
Dapsone |
Drug Info |
[4]
|
Targeted Disease |
Hansen disease |
|
Mutation Info |
Missense: T53P |
Drugs |
Drug Name |
Dapsone |
Drug Info |
[4]
|
Targeted Disease |
Hansen disease |
|
Reference |
---|
REF 1 | In vitro susceptibility of various genotypic strains of Toxoplasma gondii to pyrimethamine, sulfadiazine, and atovaquone. Antimicrob Agents Chemother. 2008 Apr;52(4):1269-77. doi: 10.1128/AAC.01203-07. Epub 2008 Jan 22. |
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REF 2 | The comprehensive antibiotic resistance database. Antimicrob Agents Chemother. 2013 Jul;57(7):3348-57. doi: 10.1128/AAC.00419-13. Epub 2013 May 6. |
---|
REF 3 | Novel K540N mutation in Plasmodium falciparum dihydropteroate synthetase confers a lower level of sulfa drug resistance than does a K540E mutation. Antimicrob Agents Chemother. 2011 May;55(5):2481-2. doi: 10.1128/AAC.01394-10. Epub 2011 Feb 22. |
---|
REF 4 | CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573. doi: 10.1093/nar/gkw1004. Epub 2016 Oct 26. |