Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T59729
|
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| Former ID |
TTDR00862
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| Target Name |
Aspartate-semialdehydedehydrogenase
|
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| Gene Name |
asd2
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| Synonyms |
ASA dehydrogenase; ASADH; L-Aspartate-beta-semialdehyde dehydrogenase; asd2
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| Target Type |
Research
|
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| Function |
Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate.
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| BioChemical Class |
Oxidoreductases acting on aldehyde or oxo group of donors
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| Target Validation |
T59729
|
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| UniProt ID | |||||
| EC Number |
EC 1.2.1.11
|
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| Sequence |
MSQQFNVAIFGATGAVGETMLEVLQEREFPVDELFLLASERSEGKTYRFNGKTVRVQNVE
EFDWSQVHIALFSAGGELSAKWAPIAAEAGVVVIDNTSHFRYDYDIPLVVPEVNPEAIAE FRNRNIIANPNCSTIQMLVALKPIYDAVGIERINVTTYQSVSGAGKAGIDELAGQTAKLL NGYPAETNTFSQQIAFNCIPQIDQFMDNGYTKEEMKMVWETQKIFNDPSIMVNPTCVRVP VFYGHAEAVHVETRAPIDAEQVMDMLEQTDGIELFRGADFPTQVRDAGGKDHVLVGRVRN DISHHSGINLWVVADNVRKGAATNAVQIAELLVRDYF |
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| Inhibitor | 2'-Monophosphoadenosine 5'-Diphosphoribose | Drug Info | [1] | ||
| Aspartate Semialdehyde | Drug Info | [1] | |||
| Cacodylate Ion | Drug Info | [1] | |||
| S-sulpho-L-cysteine | Drug Info | [2] | |||
| References | |||||
| REF 1 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
| REF 2 | J Nat Prod. 2005 May;68(5):804-6.Petrosamine B, an inhibitor of the Helicobacter pylori enzyme aspartyl semialdehyde dehydrogenase from the Australian sponge Oceanapia sp. | ||||
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