Drug General Information |
Drug ID |
D0UB6U
|
Former ID |
DNC012251
|
Drug Name |
L-687414
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Terminated |
[1]
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C5H10N2O2
|
Canonical SMILES |
CC1CN(C(=O)C1N)O
|
InChI |
1S/C5H10N2O2/c1-3-2-7(9)5(8)4(3)6/h3-4,9H,2,6H2,1H3/t3-,4-/m1/s1
|
InChIKey |
SKYSFPFYQBZGDC-QWWZWVQMSA-N
|
PubChem Compound ID |
|
Target and Pathway |
Target(s) |
Glutamate [NMDA] receptor subunit epsilon 1 |
Target Info |
Inhibitor |
[2]
|
Glutamate [NMDA] receptor subunit epsilon 2 |
Target Info |
Inhibitor |
[2]
|
NMDA receptor subunit NR1 |
Target Info |
Inhibitor |
[2]
|
KEGG Pathway
|
Ras signaling pathway
|
Rap1 signaling pathway
|
Calcium signaling pathway
|
cAMP signaling pathway
|
Neuroactive ligand-receptor interaction
|
Circadian entrainment
|
Long-term potentiation
|
Glutamatergic synapse
|
Dopaminergic synapse
|
Alzheimer's disease
|
Amyotrophic lateral sclerosis (ALS)
|
Cocaine addiction
|
Amphetamine addiction
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Nicotine addiction
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Alcoholism
|
Systemic lupus erythematosushsa04014:Ras signaling pathway
|
Huntington's disease
|
PANTHER Pathway
|
Huntington disease
|
Ionotropic glutamate receptor pathway
|
Metabotropic glutamate receptor group III pathway
|
Metabotropic glutamate receptor group I pathway
|
Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
|
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
|
Pathway Interaction Database
|
Reelin signaling pathwayerbb4_pathway:ErbB4 signaling events
|
Reelin signaling pathway
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Reactome
|
Unblocking of NMDA receptor, glutamate binding and activation
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CREB phosphorylation through the activation of CaMKII
|
Ras activation uopn Ca2+ infux through NMDA receptor
|
RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
|
RAF/MAP kinase cascade
|
WikiPathways
|
Hypothetical Network for Drug Addiction
|
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
|
Alzheimers DiseaseWP666:Hypothetical Network for Drug Addiction
|
BDNF signaling pathwayWP706:SIDS Susceptibility Pathways
|
Spinal Cord Injury
|
BDNF signaling pathway
|
Alzheimers Disease
|
References |
REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001829) |
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REF 2 | Amino acid bioisosteres: design of 2-quinolone derivatives as glycine-site N-methyl-D-aspartate receptor antagonists, Bioorg. Med. Chem. Lett. 3(2):299-304 (1993). |