Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0ZU9Z
|
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| Former ID |
DIB020277
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| Drug Name |
LY320135
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| Synonyms |
LY 320135; LY-320135
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C24H17NO4
|
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| InChI |
InChI=1S/C24H17NO4/c1-27-18-9-7-17(8-10-18)24-22(20-12-11-19(28-2)13-21(20)29-24)23(26)16-5-3-15(14-25)4-6-16/h3-13H,1-2H3
|
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| InChIKey |
RYNSGDFWBJWWSZ-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
7979825, 11056385, 14878087, 26753297, 39340961, 57309758, 57359407, 75783703, 85209155, 85788701, 103567317, 114155682, 124891595, 129200182, 135309795, 135337496, 135650548, 135698232, 136353063, 137066043, 141566793, 162023390, 162247377, 163123871, 172841720, 176227145, 184538767, 198974090, 202558953, 204369924, 215781298, 223468606, 223532833, 225373242, 229726154, 251960633, 252141330, 252156472, 252266394, 252373266, 252451046
|
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| Target and Pathway | |||||
| Target(s) | Cannabinoid receptor 1 | Target Info | Antagonist | [2] | |
| KEGG Pathway | Rap1 signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Retrograde endocannabinoid signaling | |||||
| PANTHER Pathway | Endogenous cannabinoid signaling | ||||
| Pathway Interaction Database | N-cadherin signaling events | ||||
| Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Small Ligand GPCRs | |||||
| BDNF signaling pathway | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 742). | ||||
| REF 2 | LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation. J Pharmacol Exp Ther. 1998 Jan;284(1):291-7. | ||||
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