Drug General Information |
Drug ID |
D04DKM
|
Former ID |
DIB018078
|
Drug Name |
(1S,3R)-ACPD
|
Synonyms |
(1S,3R)-1-ACPD; trans-ACPD; (1S,3S)-ACPD; 1S,3R-ACPD
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
Download
2D MOL
|
Formula |
C7H11NO4
|
InChI |
InChI=1S/C7H11NO4/c8-7(6(11)12)2-1-4(3-7)5(9)10/h4H,1-3,8H2,(H,9,10)(H,11,12)/t4-,7+/m1/s1
|
InChIKey |
YFYNOWXBIBKGHB-FBCQKBJTSA-N
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PubChem Compound ID |
|
PubChem Substance ID |
7978513, 10233597, 14772609, 17404660, 24890591, 44434377, 47736593, 47959870, 48185094, 49959005, 50104329, 50104330, 53777203, 53837809, 57337829, 79091859, 87691008, 90341793, 91702841, 92303591, 103068735, 103078459, 103204760, 103942696, 104372878, 117541915, 121360860, 124749444, 129790327, 135060901, 135365907, 135649666, 137133099, 137783325, 140862489, 144220604, 162226686, 163302678, 163564051, 164823306, 164823307, 164848256, 184526316, 212343803, 226540646, 241181603, 252645287
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Target and Pathway |
Target(s) |
mGlu6 receptor |
Target Info |
Agonist |
[2]
|
Metabotropic glutamate receptor 7 |
Target Info |
Agonist |
[3]
|
Metabotropicglutamate receptor 1 |
Target Info |
Agonist |
[4]
|
Metabotropic glutamate receptor 8 |
Target Info |
Agonist |
[5]
|
Metabotropic glutamate receptor 5 |
Target Info |
Agonist |
[4]
|
Metabotropic glutamate receptor3 |
Target Info |
Agonist |
[6]
|
Metabotropic glutamate receptor 2 |
Target Info |
Agonist |
[6]
|
KEGG Pathway
|
Neuroactive ligand-receptor interaction
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Glutamatergic synapsehsa04020:Calcium signaling pathway
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FoxO signaling pathway
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Gap junction
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Long-term potentiation
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Retrograde endocannabinoid signaling
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Glutamatergic synapse
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Long-term depression
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Estrogen signaling pathwayhsa04080:Neuroactive ligand-receptor interaction
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Huntington's diseasehsa04080:Neuroactive ligand-receptor interaction
|
Cocaine addictionhsa04080:Neuroactive ligand-receptor interaction
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Cocaine addiction
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Metabotropic glutamate receptor group III pathwayP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Metabotropic glutamate receptor group III pathway
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Metabotropic glutamate receptor group I pathway
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Endogenous cannabinoid signalingP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Ionotropic glutamate receptor pathway
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Metabotropic glutamate receptor group II pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Metabotropic glutamate receptor group II pathway
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Reactome
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G alpha (i) signalling events
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Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-416476:G alpha (q) signalling events
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Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-418594:G alpha (i) signalling events
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Class C/3 (Metabotropic glutamate/pheromone receptors)
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WikiPathways
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GPCRs, Class C Metabotropic glutamate, pheromone
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GPCR ligand binding
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GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
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Gastrin-CREB signalling pathway via PKC and MAPK
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GPCR downstream signaling
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GPCRs, OtherWP501:GPCRs, Class C Metabotropic glutamate, pheromone
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GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
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GPCR downstream signalingWP501:GPCRs, Class C Metabotropic glutamate, pheromone
|
References |
REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1365). |
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REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 294). |
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REF 3 | Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):546-54. |
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REF 4 | Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. J Neurochem. 2000 Dec;75(6):2590-601. |
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REF 5 | Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells. Brain Res Mol Brain Res. 1998 Jan;53(1-2):88-97. |
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REF 6 | [3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate (mGlu) receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells. Neuropharmacology. 1999 Oct;38(10):1519-29. |