Drug General Information |
Drug ID |
D06FHE
|
Former ID |
DNC003633
|
Drug Name |
1-Ethyl-5-(imidazol-1-yl-phenyl-methyl)-1H-indole
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
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2D MOL
3D MOL
|
Formula |
C20H19N3
|
Canonical SMILES |
CCN1C=CC2=C1C=CC(=C2)C(C3=CC=CC=C3)N4C=CN=C4
|
InChI |
1S/C20H19N3/c1-2-22-12-10-17-14-18(8-9-19(17)22)20(23-13-11-21-15-23)16-6-4-3-5-7-16/h3-15,20H,2H2,1H3
|
InChIKey |
WUILDCCEKAPXPV-UHFFFAOYSA-N
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PubChem Compound ID |
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Target and Pathway |
Target(s) |
17 alpha-hydroxylase-C17, 20-lyase |
Target Info |
Inhibitor |
[1]
|
Cytochrome P450 19 |
Target Info |
Inhibitor |
[1]
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BioCyc Pathway
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Superpathway of steroid hormone biosynthesis
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Glucocorticoid biosynthesis
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Androgen biosynthesisPWY-7305:Superpathway of steroid hormone biosynthesis
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Estradiol biosynthesis II
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Estradiol biosynthesis I
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KEGG Pathway
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Steroid hormone biosynthesis
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Metabolic pathways
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Ovarian steroidogenesis
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Prolactin signaling pathwayhsa00140:Steroid hormone biosynthesis
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NetPath Pathway
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FSH Signaling Pathway
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PANTHER Pathway
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Androgen/estrogene/progesterone biosynthesis
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PathWhiz Pathway
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Androgen and Estrogen Metabolism
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SteroidogenesisPW000045:Androgen and Estrogen Metabolism
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Reactome
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Androgen biosynthesis
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Glucocorticoid biosynthesis
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Endogenous sterolsR-HSA-211976:Endogenous sterols
|
WikiPathways
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Metapathway biotransformation
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Steroid Biosynthesis
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Oxidation by Cytochrome P450
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Metabolism of steroid hormones and vitamin D
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Glucocorticoid & Mineralcorticoid Metabolism
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Prostate Cancer
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Phase 1 - Functionalization of compoundsWP702:Metapathway biotransformation
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Tryptophan metabolism
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Ovarian Infertility Genes
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FSH signaling pathway
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Integrated Breast Cancer Pathway
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Phase 1 - Functionalization of compounds
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References |
REF 1 | Bioorg Med Chem Lett. 1999 Feb 8;9(3):333-6.New selective nonsteroidal aromatase inhibitors: synthesis and inhibitory activity of 2,3 or 5-(alpha-azolylbenzyl)-1H-indoles. |