Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00PJT
|
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| Former ID |
DNC010291
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| Drug Name |
(S)(+)-7-fluoro-2-p-tolylchroman-4-one
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C16H13FO2
|
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| Canonical SMILES |
CC1=CC=C(C=C1)C2CC(=O)C3=C(O2)C=C(C=C3)F
|
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| InChI |
1S/C16H13FO2/c1-10-2-4-11(5-3-10)15-9-14(18)13-7-6-12(17)8-16(13)19-15/h2-8,15H,9H2,1H3/t15-/m0/s1
|
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| InChIKey |
QNQXLNDULBVXEX-HNNXBMFYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Amine oxidase [flavin-containing] B | Target Info | Inhibitor | [1] | |
| BioCyc Pathway | Superpathway of tryptophan utilization | ||||
| Tryptophan degradation via tryptamine | |||||
| Dopamine degradation | |||||
| Putrescine degradation III | |||||
| Noradrenaline and adrenaline degradation | |||||
| KEGG Pathway | Glycine, serine and threonine metabolism | ||||
| Arginine and proline metabolism | |||||
| Histidine metabolism | |||||
| Tyrosine metabolism | |||||
| Phenylalanine metabolism | |||||
| Tryptophan metabolism | |||||
| Drug metabolism - cytochrome P450 | |||||
| Metabolic pathways | |||||
| Serotonergic synapse | |||||
| Dopaminergic synapse | |||||
| Cocaine addiction | |||||
| Amphetamine addiction | |||||
| Alcoholism | |||||
| PANTHER Pathway | Adrenaline and noradrenaline biosynthesis | ||||
| 5-Hydroxytryptamine degredation | |||||
| Dopamine receptor mediated signaling pathway | |||||
| Pathway Interaction Database | Alpha-synuclein signaling | ||||
| WikiPathways | Tryptophan metabolism | ||||
| Dopamine metabolism | |||||
| Phase 1 - Functionalization of compounds | |||||
| References | |||||
| REF 1 | Bioorg Med Chem. 2010 Feb;18(3):1273-9. Epub 2010 Jan 4.A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. | ||||
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