| Drug General Information |
| Drug ID |
D0L0MZ
|
| Former ID |
DNC007385
|
| Drug Name |
Bis(5-acetoxybenzo[b]furan-2-yl)methanone
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C21H14O7
|
| Canonical SMILES |
CC(=O)OC1=CC2=C(C=C1)OC(=C2)C(=O)C3=CC4=C(O3)C=CC(=C4)O<br />C(=O)C
|
| InChI |
1S/C21H14O7/c1-11(22)25-15-3-5-17-13(7-15)9-19(27-17)21(24)20-10-14-8-16(26-12(2)23)4-6-18(14)28-20/h3-10H,1-2H3
|
| InChIKey |
UACDZFCKAGJOFV-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Beta platelet-derived growth factor receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| FL cytokine receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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MAPK signaling pathway
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Ras signaling pathway
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Rap1 signaling pathway
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Calcium signaling pathway
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Cytokine-cytokine receptor interaction
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PI3K-Akt signaling pathway
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Focal adhesion
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Gap junction
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Regulation of actin cytoskeleton
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HTLV-I infection
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Pathways in cancer
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MicroRNAs in cancer
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Glioma
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Prostate cancer
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Melanoma
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Central carbon metabolism in cancer
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Choline metabolism in cancerhsa04060:Cytokine-cytokine receptor interaction
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Hematopoietic cell lineage
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Transcriptional misregulation in cancer
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Acute myeloid leukemia
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PANTHER Pathway
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Angiogenesis
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PDGF signaling pathway
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Pathway Interaction Database
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Signaling events mediated by PTP1B
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Beta3 integrin cell surface interactions
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S1P3 pathway
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Nectin adhesion pathway
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Signaling events mediated by TCPTP
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SHP2 signaling
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S1P1 pathway
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Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
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PDGFR-beta signaling pathway
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Validated targets of C-MYC transcriptional repression
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PDGF receptor signaling network
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Reactome
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PIP3 activates AKT signaling
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Constitutive Signaling by Aberrant PI3K in Cancer
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RAF/MAP kinase cascade
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WikiPathways
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Regulation of Actin Cytoskeleton
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MAPK Signaling Pathway
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Osteoblast Signaling
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Focal Adhesion
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PIP3 activates AKT signaling
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PDGF Pathway
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Signaling Pathways in Glioblastoma
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Signaling by PDGF
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| References |
| REF 1 | Bioorg Med Chem. 2007 Mar 1;15(5):2187-97. Epub 2006 Dec 12.Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones. |
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