Drug General Information |
Drug ID |
D01VUF
|
Former ID |
DNC000862
|
Drug Name |
Laudanosine
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C21H27NO4
|
Canonical SMILES |
CN1CCC2=CC(=C(C=C2C1CC3=CC(=C(C=C3)OC)OC)OC)OC
|
InChI |
1S/C21H27NO4/c1-22-9-8-15-12-20(25-4)21(26-5)13-16(15)17(22)10-14-6-7-18(23-2)19(11-14)24-3/h6-7,11-13,17H,8-10H2,1-5H3
|
InChIKey |
KGPAYJZAMGEDIQ-UHFFFAOYSA-N
|
CAS Number |
CAS 1699-51-0
|
PubChem Compound ID |
|
PubChem Substance ID |
92363, 399634, 459197, 3134993, 3715869, 5338659, 8138172, 8161679, 10321374, 10512897, 11341359, 11361542, 11363757, 11366319, 11368881, 11370964, 11374626, 11377043, 11466619, 11467739, 11484461, 11486417, 11486944, 11488479, 11489928, 11492749, 11494677, 15423389, 26680393, 26754143, 29204322, 29283496, 47365460, 47440553, 47662547, 47885662, 47960017, 48185246, 48185247, 48463331, 49698825, 49747919, 49986969, 50267717, 56242095, 57329048, 85787872, 88771139, 92125428, 93576858
|
Target and Pathway |
Target(s) |
Neuronal acetylcholine receptor protein, alpha-7 chain |
Target Info |
Antagonist |
[1]
|
Neuronal acetylcholine receptor protein, beta-2 chain |
Target Info |
Antagonist |
[1]
|
Nicotinic acetylcholine receptoralpha2 / alpha3 |
Target Info |
Antagonist |
[1]
|
KEGG Pathway
|
Calcium signaling pathway
|
Neuroactive ligand-receptor interaction
|
Cholinergic synapse
|
Nicotine addiction
|
Chemical carcinogenesishsa04080:Neuroactive ligand-receptor interaction
|
PANTHER Pathway
|
Alzheimer disease-amyloid secretase pathway
|
Nicotinic acetylcholine receptor signaling pathwayP00044:Nicotinic acetylcholine receptor signaling pathway
|
Nicotine pharmacodynamics pathway
|
Reactome
|
Highly calcium permeable postsynaptic nicotinic acetylcholine receptorsR-HSA-629587:Highly sodium permeable acetylcholine nicotinic receptors
|
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
|
Highly calcium permeable nicotinic acetylcholine receptors
|
WikiPathways
|
SIDS Susceptibility Pathways
|
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellWP706:SIDS Susceptibility Pathways
|
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
|
Nicotine Activity on Dopaminergic Neurons
|
References |
REF 1 | Blockade and activation of the human neuronal nicotinic acetylcholine receptors by atracurium and laudanosine. Anesthesiology. 2001 Apr;94(4):643-51. |