Drug General Information |
Drug ID |
D0W7JF
|
Former ID |
DNC013010
|
Drug Name |
6-cyano-7-nitroquinoxaline-2,3-dione
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Formula |
C9H4N4O4
|
InChI |
InChI=1S/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15)
|
InChIKey |
RPXVIAFEQBNEAX-UHFFFAOYSA-N
|
PubChem Compound ID |
|
PubChem Substance ID |
586261, 3153197, 6755090, 7978981, 9848633, 11113401, 14749366, 14798224, 15366159, 16959940, 24892392, 26751641, 41107183, 47216988, 47515531, 48110666, 49738150, 50064192, 50620523, 53790056, 57356507, 84943270, 85085024, 85787585, 85787788, 88813857, 89651136, 95515025, 103509728, 104084998, 109614636, 112157853, 118507699, 125388318, 129164847, 135016987, 137045682, 139216164, 140361328, 141003657, 143551540, 162022475, 162079659, 166732091, 178100904, 178102124, 179293798, 184580095, 198982161, 216088070
|
Target and Pathway |
Target(s) |
Glutamate receptor AMPA subtype |
Target Info |
Inhibitor |
[2]
|
Glutamate receptor 1 |
Target Info |
Inhibitor |
[2]
|
KEGG Pathway
|
cAMP signaling pathway
|
Neuroactive ligand-receptor interaction
|
Circadian entrainment
|
Long-term potentiation
|
Retrograde endocannabinoid signaling
|
Glutamatergic synapse
|
Dopaminergic synapse
|
Long-term depression
|
Amyotrophic lateral sclerosis (ALS)
|
Amphetamine addiction
|
Nicotine addiction
|
PANTHER Pathway
|
Ionotropic glutamate receptor pathway
|
Metabotropic glutamate receptor group III pathway
|
Pathway Interaction Database
|
EPHB forward signaling
|
Reactome
|
COPII (Coat Protein 2) Mediated Vesicle Transport
|
Trafficking of AMPA receptors
|
Trafficking of GluR2-containing AMPA receptors
|
Unblocking of NMDA receptor, glutamate binding and activation
|
Cargo concentration in the ER
|
WikiPathways
|
Hypothetical Network for Drug Addiction
|
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
|
Amyotrophic lateral sclerosis (ALS)
|
BDNF signaling pathway
|
References |
REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5475). |
---|
REF 2 | J Med Chem. 2006 Apr 20;49(8):2579-92.Structure-activity relationship studies on N3-substituted willardiine derivatives acting as AMPA or kainate receptor antagonists. |