Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D06IMY
|
||||
| Former ID |
DNC009950
|
||||
| Drug Name |
N-hydroxy-9H-xanthene-9-carboxamide
|
||||
| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C14H11NO3
|
||||
| Canonical SMILES |
C1=CC=C2C(=C1)C(C3=CC=CC=C3O2)C(=O)NO
|
||||
| InChI |
1S/C14H11NO3/c16-14(15-17)13-9-5-1-3-7-11(9)18-12-8-4-2-6-10(12)13/h1-8,13,17H,(H,15,16)
|
||||
| InChIKey |
ULUVQBMMAOHWSH-UHFFFAOYSA-N
|
||||
| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Histone deacetylase | Target Info | Inhibitor | [1] | |
| Histone deacetylase 4 | Target Info | Inhibitor | [1] | ||
| KEGG Pathway | Alcoholism | ||||
| Epstein-Barr virus infection | |||||
| Viral carcinogenesis | |||||
| MicroRNAs in cancer | |||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| Pathway Interaction Database | Signaling events mediated by HDAC Class II | ||||
| Signaling events mediated by HDAC Class III | |||||
| Signaling events mediated by HDAC Class I | |||||
| Sumoylation by RanBP2 regulates transcriptional repression | |||||
| Validated nuclear estrogen receptor alpha network | |||||
| Reactome | NOTCH1 Intracellular Domain Regulates Transcription | ||||
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | |||||
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |||||
| WikiPathways | Endochondral Ossification | ||||
| Cardiac Hypertrophic Response | |||||
| Neural Crest Differentiation | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| miR-targeted genes in lymphocytes - TarBase | |||||
| miR-targeted genes in epithelium - TarBase | |||||
| TarBasePathway | |||||
| Cell Cycle | |||||
| MicroRNAs in cardiomyocyte hypertrophy | |||||
| References | |||||
| REF 1 | Bioorg Med Chem Lett. 2009 Oct 1;19(19):5684-8. Epub 2009 Aug 7.Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. | ||||
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