| Drug General Information |
| Drug ID |
D0QT4X
|
| Former ID |
DNC003795
|
| Drug Name |
6,7-Difluoro-3-thiophen-3-yl-quinoline
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C13H7F2NS
|
| Canonical SMILES |
C1=CSC=C1C2=CN=C3C=C(C(=CC3=C2)F)F
|
| InChI |
1S/C13H7F2NS/c14-11-4-9-3-10(8-1-2-17-7-8)6-16-13(9)5-12(11)15/h1-7H
|
| InChIKey |
RAEOQRGQVOSWAJ-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Beta platelet-derived growth factor receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Alpha platelet-derived growth factor receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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MAPK signaling pathway
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Ras signaling pathway
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Rap1 signaling pathway
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Calcium signaling pathway
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Cytokine-cytokine receptor interaction
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PI3K-Akt signaling pathway
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Focal adhesion
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Gap junction
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Regulation of actin cytoskeleton
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HTLV-I infection
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Pathways in cancer
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MicroRNAs in cancer
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Glioma
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Prostate cancer
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Melanoma
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Central carbon metabolism in cancer
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Choline metabolism in cancerhsa04010:MAPK signaling pathway
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Endocytosis
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Choline metabolism in cancer
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NetPath Pathway
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TGF_beta_Receptor Signaling Pathway
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PANTHER Pathway
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Angiogenesis
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PDGF signaling pathwayP00005:Angiogenesis
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PDGF signaling pathway
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Pathway Interaction Database
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Signaling events mediated by PTP1B
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Beta3 integrin cell surface interactions
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S1P3 pathway
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Nectin adhesion pathway
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Signaling events mediated by TCPTP
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SHP2 signaling
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S1P1 pathway
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Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
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PDGFR-beta signaling pathway
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Validated targets of C-MYC transcriptional repression
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PDGF receptor signaling networkatf2_pathway:ATF-2 transcription factor network
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PDGFR-alpha signaling pathway
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PDGF receptor signaling network
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Reactome
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PIP3 activates AKT signaling
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Constitutive Signaling by Aberrant PI3K in Cancer
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RAF/MAP kinase cascadeR-HSA-1257604:PIP3 activates AKT signaling
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RAF/MAP kinase cascade
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WikiPathways
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Regulation of Actin Cytoskeleton
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MAPK Signaling Pathway
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Osteoblast Signaling
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Focal Adhesion
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PIP3 activates AKT signaling
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PDGF Pathway
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Signaling Pathways in Glioblastoma
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Signaling by PDGFWP51:Regulation of Actin Cytoskeleton
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Hair Follicle Development: Organogenesis (Part 2 of 3)
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Cardiac Progenitor Differentiation
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Integrated Pancreatic Cancer Pathway
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Allograft Rejection
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Signaling by PDGF
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Angiogenesis
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| References |
| REF 1 | J Med Chem. 1994 Jul 8;37(14):2129-37.A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. |
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