Drug Information

Drug General Information
Drug ID
D0T7QF
Former ID
DNC006242
Drug Name
(S)-tert-butyl 1-oxohexan-2-ylcarbamate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [1]
Structure
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2D MOL

3D MOL
Formula
C11H21NO3
Canonical SMILES
CCCCC(C=O)NC(=O)OC(C)(C)C
InChI
1S/C11H21NO3/c1-5-6-7-9(8-13)12-10(14)15-11(2,3)4/h8-9H,5-7H2,1-4H3,(H,12,14)/t9-/m0/s1
InChIKey
OBMGXPJNZKYOQY-VIFPVBQESA-N
PubChem Compound ID
10420833
Target and Pathway
Target(s) Cathepsin L Target Info Inhibitor [1]
Cathepsin K Target Info Inhibitor [1]
KEGG Pathway Lysosome
Phagosome
Antigen processing and presentation
Proteoglycans in cancer
Rheumatoid arthritishsa04142:Lysosome
Osteoclast differentiation
Toll-like receptor signaling pathway
Rheumatoid arthritis
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
RANKL Signaling Pathway
IL2 Signaling Pathway
Reactome Endosomal/Vacuolar pathway
Collagen degradation
Degradation of the extracellular matrix
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentationR-HSA-1442490:Collagen degradation
Activation of Matrix Metalloproteinases
MHC class II antigen presentation
WikiPathways Primary Focal Segmental Glomerulosclerosis FSGSWP2018:RANKL/RANK Signaling Pathway
Osteoclast Signaling
References
REF 1Bioorg Med Chem Lett. 2006 Feb 15;16(4):978-83. Epub 2005 Nov 15.Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors?.

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