Drug Information
Drug General Information | |||||
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Drug ID |
D0K9YR
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Former ID |
DNC010135
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Drug Name |
SCH-54470
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Terminated | [1] | ||
Structure |
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Download2D MOL |
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Formula |
C33H46N5O8PS
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Canonical SMILES |
CS(=O)(=O)NC(CCCCN)C(=O)NC(CC1=CC=CC=C1)P(=O)(CC2(CCCC2<br />)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)O)O
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InChI |
1S/C33H46N5O8PS/c1-48(45,46)38-27(15-7-10-18-34)30(39)37-29(19-23-11-3-2-4-12-23)47(43,44)22-33(16-8-9-17-33)32(42)36-28(31(40)41)20-24-21-35-26-14-6-5-13-25(24)26/h2-6,11-14,21,27-29,35,38H,7-10,15-20,22,34H2,1H3,(H,36,42)(H,37,39)(H,40,41)(H,43,44)/t27-,28-,29+/m0/s1
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InChIKey |
UBQFBYMIHFXWBF-YTCPBCGMSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Angiotensin-converting enzyme | Target Info | Inhibitor | [2] | |
Endothelin-converting enzyme 1 | Target Info | Inhibitor | [2] | ||
Neutral endopeptidase | Target Info | Inhibitor | [2] | ||
KEGG Pathway | Renin-angiotensin system | ||||
Chagas disease (American trypanosomiasis) | |||||
Hypertrophic cardiomyopathy (HCM)hsa04614:Renin-angiotensin system | |||||
Hematopoietic cell lineage | |||||
Protein digestion and absorption | |||||
Alzheimer's disease | |||||
NetPath Pathway | EGFR1 Signaling Pathway | ||||
TGF_beta_Receptor Signaling Pathway | |||||
PANTHER Pathway | Endothelin signaling pathway | ||||
PathWhiz Pathway | Angiotensin Metabolism | ||||
Reactome | Metabolism of Angiotensinogen to AngiotensinsR-HSA-2022377:Metabolism of Angiotensinogen to Angiotensins | ||||
WikiPathways | ACE Inhibitor Pathway | ||||
Metabolism of Angiotensinogen to AngiotensinsWP706:SIDS Susceptibility Pathways | |||||
Corticotropin-releasing hormone | |||||
Endothelin PathwaysWP2729:Metabolism of Angiotensinogen to Angiotensins | |||||
Primary Focal Segmental Glomerulosclerosis FSGS | |||||
Alzheimers Disease | |||||
References | |||||
REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007872) | ||||
REF 2 | J Med Chem. 2010 Jan 14;53(1):208-20.Phosphinic tripeptides as dual angiotensin-converting enzyme C-domain and endothelin-converting enzyme-1 inhibitors. | ||||
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