Drug General Information |
Drug ID |
D0U0ZE
|
Former ID |
DNC006330
|
Drug Name |
3-hydroxy-8,10-dimethyl-6H-benzo[c]chromen-6-one
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C15H12O3
|
Canonical SMILES |
CC1=CC(=C2C3=C(C=C(C=C3)O)OC(=O)C2=C1)C
|
InChI |
1S/C15H12O3/c1-8-5-9(2)14-11-4-3-10(16)7-13(11)18-15(17)12(14)6-8/h3-7,16H,1-2H3
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InChIKey |
LTZNXKCOWADUFT-UHFFFAOYSA-N
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PubChem Compound ID |
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Target and Pathway |
Target(s) |
Estrogen receptor |
Target Info |
Inhibitor |
[1]
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Estrogen receptor beta |
Target Info |
Inhibitor |
[1]
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KEGG Pathway
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Estrogen signaling pathway
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Prolactin signaling pathway
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Thyroid hormone signaling pathway
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Endocrine and other factor-regulated calcium reabsorption
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Proteoglycans in cancerhsa04915:Estrogen signaling pathway
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NetPath Pathway
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FSH Signaling Pathway
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EGFR1 Signaling Pathway
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RANKL Signaling Pathway
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Pathway Interaction Database
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Regulation of nuclear SMAD2/3 signaling
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Signaling events mediated by HDAC Class II
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Plasma membrane estrogen receptor signaling
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LKB1 signaling events
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Regulation of Telomerase
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ATF-2 transcription factor network
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AP-1 transcription factor network
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FOXM1 transcription factor network
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Validated nuclear estrogen receptor alpha network
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Signaling mediated by p38-alpha and p38-beta
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FOXA1 transcription factor networker_nongenomic_pathway:Plasma membrane estrogen receptor signaling
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Validated nuclear estrogen receptor beta network
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Reactome
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Nuclear signaling by ERBB4
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Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathway
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WikiPathways
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Estrogen signaling pathway
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Nuclear Receptors Meta-Pathway
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Estrogen Receptor Pathway
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Signaling by ERBB4
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JAK/STAT
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Integrated Pancreatic Cancer Pathway
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Leptin signaling pathway
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miR-targeted genes in muscle cell - TarBase
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Integrated Breast Cancer Pathway
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Nuclear ReceptorsWP706:SIDS Susceptibility Pathways
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Ovarian Infertility Genes
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Nuclear Receptors
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References |
REF 1 | Bioorg Med Chem Lett. 2006 Mar 15;16(6):1468-72. Epub 2006 Jan 18.6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists. |