| Drug General Information |
| Drug ID |
D0L5GS
|
| Former ID |
DNC010637
|
| Drug Name |
4-(Quinolin-4-yl)-N-p-tolylpyrimidin-2-amine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C20H16N4
|
| Canonical SMILES |
CC1=CC=C(C=C1)NC2=NC=CC(=N2)C3=CC=NC4=CC=CC=C34
|
| InChI |
1S/C20H16N4/c1-14-6-8-15(9-7-14)23-20-22-13-11-19(24-20)17-10-12-21-18-5-3-2-4-16(17)18/h2-13H,1H3,(H,22,23,24)
|
| InChIKey |
HFJKLAQBWSUMDJ-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Cell division control protein 2 homolog |
Target Info |
Inhibitor |
[1]
|
|---|
| G2/mitotic-specific cyclin B1 |
Target Info |
Inhibitor |
[1]
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KEGG Pathway
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Cell cycle
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Oocyte meiosis
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p53 signaling pathway
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Gap junction
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Progesterone-mediated oocyte maturation
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Herpes simplex infection
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Epstein-Barr virus infection
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Viral carcinogenesishsa04068:FoxO signaling pathway
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NetPath Pathway
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RANKL Signaling PathwayNetPath_11:TCR Signaling Pathway
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PANTHER Pathway
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p53 pathway
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Pathway Interaction Database
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p73 transcription factor network
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E2F transcription factor network
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PLK1 signaling events
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AP-1 transcription factor network
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FOXM1 transcription factor network
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Retinoic acid receptors-mediated signalingp73pathway:p73 transcription factor network
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Validated targets of C-MYC transcriptional activation
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FoxO family signaling
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Direct p53 effectors
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C-MYB transcription factor network
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Reactome
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MAPK3 (ERK1) activation
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E2F mediated regulation of DNA replication
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G0 and Early G1
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Cyclin B2 mediated events
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Golgi Cisternae Pericentriolar Stack Reorganization
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Cdc20:Phospho-APC/C mediated degradation of Cyclin A
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Regulation of APC/C activators between G1/S and early anaphase
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Phosphorylation of the APC/C
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Phosphorylation of Emi1
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Condensation of Prophase Chromosomes
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MASTL Facilitates Mitotic Progression
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Resolution of Sister Chromatid Cohesion
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Condensation of Prometaphase Chromosomes
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Regulation of PLK1 Activity at G2/M Transition
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Activation of NIMA Kinases NEK9, NEK6, NEK7
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Loss of Nlp from mitotic centrosomes
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Recruitment of mitotic centrosome proteins and complexes
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Loss of proteins required for interphase microtubule organization?from the centrosome
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Recruitment of NuMA to mitotic centrosomes
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Depolymerisation of the Nuclear Lamina
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Anchoring of the basal body to the plasma membrane
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MAPK6/MAPK4 signaling
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G1/S-Specific Transcription
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Cyclin A/B1 associated events during G2/M transition
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G2/M DNA replication checkpoint
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Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexR-HSA-156711:Polo-like kinase mediated events
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Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
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WikiPathways
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DNA Damage Response
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G1 to S cell cycle control
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TGF beta Signaling Pathway
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PPAR Alpha Pathway
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MAP kinase activation in TLR cascade
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RAF/MAP kinase cascade
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Mitotic Prophase
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Mitotic Prometaphase
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BMI1
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ATM Signaling Pathway
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Retinoblastoma (RB) in Cancer
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Spinal Cord Injury
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Prostate Cancer
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Regulation of Microtubule Cytoskeleton
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Integrated Cancer pathway
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Mitotic G2-G2/M phases
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Mitotic G1-G1/S phases
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Cell Cycle
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APC/C-mediated degradation of cell cycle proteins
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Cell Cycle Checkpoints
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miRNA Regulation of DNA Damage ResponseWP707:DNA Damage Response
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miRNA Regulation of DNA Damage Response
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AMPK Signaling
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| References |
| REF 1 | Eur J Med Chem. 2010 Jan;45(1):379-86. Epub 2009 Oct 13.Synthesis and cytotoxic activity of 2-methylimidazo[1,2-a]pyridine- and quinoline-substituted 2-aminopyrimidine derivatives. |
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